Live porcine reproductive and respiratory syndrome virus vaccines: current status and future direction

GJ Renukaradhya, XJ Meng, JG Calvert, M Roof… - Vaccine, 2015 - Elsevier
Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV)
was reported in the late 1980s. PRRS still is a huge economic concern to the global pig …

Engineering the PRRS virus genome: Updates and perspectives

M Han, D Yoo - Veterinary microbiology, 2014 - Elsevier
Porcine reproductive and respiratory syndrome virus (PRRSV) is endemic in most pig
producing countries worldwide and causes enormous economic losses to the pork industry …

Research progress on NSP11 of porcine reproductive and respiratory syndrome virus

Y Zheng, H Zhang, Q Luo, H Sha, G Li, X Mu, Y He… - Veterinary …, 2023 - mdpi.com
Simple Summary NSP11 is a non-structural protein of the porcine reproductive and
respiratory syndrome virus (PRRSV) that influences viral replication and interacts with the …

Reverse genetics construction and pathogenicity of a novel recombinant NADC30-like PRRSV isolated in China

J Guo, C Li, H Lu, B Wang, L Zhang, J Ding… - Frontiers in Veterinary …, 2024 - frontiersin.org
China has the largest pig herd in the world which accounts for more than 50% of the global
pig population. Over the past three decades, the porcine reproductive and respiratory …

Porcine reproductive and respiratory syndrome virus ORF5a protein is essential for virus viability

L Sun, Y Li, R Liu, X Wang, F Gao, T Lin, T Huang… - Virus research, 2013 - Elsevier
It has been shown that ORF5a protein in EAV is important but not essential for virus
infectivity. In this study, we found that RNA changes in the overlapping region (1–104 …

A novel amino acid site of N protein could affect the PRRSV-2 replication by regulating the viral RNA transcription

H Deng, N Xin, F Zeng, F Wen, H Yi, C Ma… - BMC Veterinary …, 2022 - Springer
Background Finding the key amino acid sites that could affect viral biological properties or
protein functions has always been a topic of substantial interest in virology. The …

Effect of the host cell line on the vaccine efficacy of an attenuated porcine reproductive and respiratory syndrome virus

G Calzada-Nova, RJ Husmann, WM Schnitzlein… - Veterinary immunology …, 2012 - Elsevier
The abilities of the modified-live Prime Pac (PP) strain of porcine reproductive and
respiratory syndrome virus (PRRSV), propagated in either traditional simian cells (MARC …

Research progress in the development of porcine reproductive and respiratory syndrome virus as a viral vector for foreign gene expression and delivery

G Dai, M Huang, TS Fung, DX Liu - Expert Review of Vaccines, 2020 - Taylor & Francis
Introduction Porcine reproductive and respiratory syndrome (PRRS) is an infectious disease
of swine characterized by respiratory disorders in growing and finishing pigs and …

Serine 105 and 120 are important phosphorylation sites for porcine reproductive and respiratory syndrome virus N protein function

Y Chen, X Xing, Q Li, S Feng, X Han, S He… - Veterinary …, 2018 - Elsevier
The nucleocapsid (N) protein is the most abundant protein of porcine reproductive and
respiratory syndrome virus (PRRSV). It has been shown to be multiphosphorylated …

Cysteine residues of the porcine reproductive and respiratory syndrome virus ORF5a protein are not essential for virus viability

L Sun, Y Zhou, R Liu, Y Li, F Gao, X Wang, H Fan… - Virus research, 2015 - Elsevier
ORF5a protein was recently identified as a novel structural protein in porcine reproductive
and respiratory syndrome virus (PRRSV). The ORF5a protein possesses two cysteines at …