International AIDS Society global scientific strategy: towards an HIV cure 2016
Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …
global population of more than 35 million people living with HIV, there is intense interest in …
Euphorbia diterpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)
Z Zhan, S Li, W Chu, S Yin - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2013 to 2021 As the characteristic metabolites of Euphorbia plants, Euphorbia
diterpenoids have always been a hot topic in related science communities due to their …
diterpenoids have always been a hot topic in related science communities due to their …
The role of macrophages in HIV-1 persistence and pathogenesis
Z Kruize, NA Kootstra - Frontiers in microbiology, 2019 - frontiersin.org
Current antiretroviral therapy (ART) effectively suppresses Human Immunodeficiency Virus
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …
The current status of latency reversing agents for HIV-1 remission
A Rodari, G Darcis, CM Van Lint - Annual review of virology, 2021 - annualreviews.org
Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1
(HIV-1) replication but is not curative because cART interruption almost invariably leads to a …
(HIV-1) replication but is not curative because cART interruption almost invariably leads to a …
Current status of latency reversing agents facing the heterogeneity of HIV-1 cellular and tissue reservoirs
One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
HIV “shock and kill” therapy: In need of revision
The implementation of antiretroviral therapy 23 years ago has rendered HIV infection
clinically manageable. However, the disease remains incurable, since it establishes latent …
clinically manageable. However, the disease remains incurable, since it establishes latent …
Latency reversal agents affect differently the latent reservoir present in distinct CD4+ T subpopulations
J Grau-Expósito, L Luque-Ballesteros, J Navarro… - PLoS …, 2019 - journals.plos.org
Latency reversal agents (LRAs) have proven to induce HIV-1 transcription in vivo but are
ineffective at decreasing the size of the latent reservoir in antiretroviral treated patients. The …
ineffective at decreasing the size of the latent reservoir in antiretroviral treated patients. The …
An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B …
The persistence of latently infected cells in patients under combinatory antiretroviral therapy
(cART) is a major hurdle to HIV-1 eradication. Strategies to purge these reservoirs are …
(cART) is a major hurdle to HIV-1 eradication. Strategies to purge these reservoirs are …
Novel latency reversal agents for HIV-1 cure
AM Spivak, V Planelles - Annual review of medicine, 2018 - annualreviews.org
Antiretroviral therapy (ART) has rendered HIV-1 infection a treatable illness; however, ART
is not curative owing to the persistence of replication-competent, latent proviruses in long …
is not curative owing to the persistence of replication-competent, latent proviruses in long …
Synergistic reactivation of latent HIV expression by ingenol-3-angelate, PEP005, targeted NF-kB signaling in combination with JQ1 induced p-TEFb activation
Although anti-retroviral therapy (ART) is highly effective in suppressing HIV replication, it
fails to eradicate the virus from HIV-infected individuals. Stable latent HIV reservoirs are …
fails to eradicate the virus from HIV-infected individuals. Stable latent HIV reservoirs are …