The Brucella Cell Envelope

MA Alakavuklar, A Fiebig… - Annual review of …, 2023 - annualreviews.org
The cell envelope is a multilayered structure that insulates the interior of bacterial cells from
an often chaotic outside world. Common features define the envelope across the bacterial …

Brucella MucR acts as an H-NS-like protein to silence virulence genes and structure the nucleoid

IS Barton, Z Ren, CB Cribb, JE Pitzer, I Baglivo… - MBio, 2023 - Am Soc Microbiol
Histone-like nucleoid structuring (H-NS) and H-NS-like proteins serve as global gene
silencers and work with antagonistic transcriptional activators (counter-silencers) to properly …

A bvrR/bvrS Non-Polar Brucella abortus Mutant Confirms the Role of the Two-Component System BvrR/BvrS in Virulence and Membrane Integrity

O Rivas-Solano, K Núñez-Montero, P Altamirano-Silva… - Microorganisms, 2023 - mdpi.com
Brucella abortus is a bacterial pathogen causing bovine brucellosis worldwide. This
facultative extracellular–intracellular pathogen can be transmitted to humans, leading to a …

Bioinformatics approach for structure modeling, vaccine design, and molecular docking of Brucella candidate proteins BvrR, OMP25, and OMP31

A Elrashedy, M Nayel, A Salama, MM Salama… - Scientific Reports, 2024 - nature.com
Brucellosis is a zoonotic disease with significant economic and healthcare costs. Despite the
eradication efforts, the disease persists. Vaccines prevent disease in animals while …

A protease and a lipoprotein jointly modulate the conserved ExoR-ExoS-ChvI signaling pathway critical in Sinorhizobium meliloti for symbiosis with legume hosts

JA Bustamante, JS Ceron, IT Gao, HA Ramirez… - PLoS …, 2023 - journals.plos.org
Sinorhizobium meliloti is a model alpha-proteobacterium for investigating microbe-host
interactions, in particular nitrogen-fixing rhizobium-legume symbioses. Successful infection …

The Brucella abortus two-component system response regulator BvrR binds to three DNA regulatory boxes in the upstream region of omp25

A Castillo-Zeledón, O Rivas-Solano… - Frontiers in …, 2023 - frontiersin.org
Brucella abortus is a facultative extracellular-intracellular bacterial zoonotic pathogen
worldwide. It is also a major cause of abortion in bovines, generating economic losses. The …

[HTML][HTML] A sensor histidine kinase from a plant-endosymbiont bacterium restores the virulence of a mammalian intracellular pathogen

E Chaves-Olarte, J Meza-Torres… - Microbial …, 2023 - Elsevier
Alphaproteobacteria include organisms living in close association with plants or animals.
This interaction relies partly on orthologous two-component regulatory systems (TCS), with …

Phenotypes controlled by the Brucella abortus two component system BvrR/BvrS are differentially impacted by BvrR phosphorylation

P Altamirano-Silva, J Meza-Torres… - Frontiers in …, 2023 - frontiersin.org
Brucella abortus is a zoonotic pathogen whose virulence depends on its ability to survive
intracellularly at the endoplasmic reticulum derived compartment. The two-component …

Increased Brucella abortus asRNA_0067 expression under intraphagocytic stressors is associated with enhanced virB2 transcription

A Muñoz-Bucio, B Arellano-Reynoso, FJ Sangari… - Archives of …, 2024 - Springer
Intracellular pathogens like Brucella face challenges during the intraphagocytic adaptation
phase, where the modulation of gene expression plays an essential role in taking advantage …

A genome-wide CRISPR screen identified host genes essential for intracellular Brucella survival

H Xu, J Lu, F Huang, Q Zhang, S Liu… - Microbiology …, 2024 - Am Soc Microbiol
Brucella is a zoonotic intracellular bacterium that poses threats to human health and
economic security. Intracellular infection is a hallmark of the agent Brucella and a primary …