Luminescent and photofunctional transition metal complexes: From molecular design to diagnostic and therapeutic applications

LCC Lee, KKW Lo - Journal of the American Chemical Society, 2022 - ACS Publications
There has been emerging interest in the exploitation of the photophysical and
photochemical properties of transition metal complexes for diagnostic and therapeutic …

Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024 - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Bioorthogonal reactions utilizing nitrones as versatile dipoles in cycloaddition reactions

DA Bilodeau, KD Margison, M Serhan… - Chemical …, 2021 - ACS Publications
Bioorthogonal chemical reactions have emerged as convenient and rapid methods for
incorporating unnatural functionality into living systems. Different prototype reactions have …

Recent progress in the design principles, sensing mechanisms, and applications of small-molecule probes for nitroreductases

YL Qi, L Guo, LL Chen, H Li, YS Yang, AQ Jiang… - Coordination Chemistry …, 2020 - Elsevier
As one of the most representative hypoxic enzymes, nitroreductases (NTRs) play
momentous roles in malignant tumor progression, metastasis, invasion and angiogenesis …

Bioorthogonally Assisted Phototherapy: Recent Advances and Prospects

E Kozma, M Bojtár, P Kele - Angewandte Chemie International …, 2023 - Wiley Online Library
Photoresponsive materials offer excellent spatiotemporal control over biological processes
and the emerging phototherapeutic methods are expected to have significant effects on …

Phosphorogenic Iridium(III) bis‐Tetrazine Complexes for Bioorthogonal Peptide Stapling, Bioimaging, Photocytotoxic Applications, and the Construction of Nanosized …

AMH Yip, CKH Lai, KSM Yiu, KKW Lo - Angewandte Chemie, 2022 - Wiley Online Library
Abstract The dual functionality of 1, 2, 4, 5‐tetrazine as a bioorthogonal reactive unit and a
luminescence quencher has shaped tetrazine‐based probes as attractive candidates for …

Photofunctional transition metal complexes as cellular probes, bioimaging reagents and phototherapeutics

GX Xu, ECL Mak, KKW Lo - Inorganic Chemistry Frontiers, 2021 - pubs.rsc.org
By virtue of their rich photophysical and photochemical properties, transition metal
complexes (TMCs) have been extensively studied in multidisciplinary research. In this …

Induction of Paraptosis by Cyclometalated Iridium Complex-Peptide Hybrids and CGP37157 via a Mitochondrial Ca2+ Overload Triggered by Membrane Fusion …

K Yokoi, K Yamaguchi, M Umezawa, K Tsuchiya… - Biochemistry, 2022 - ACS Publications
We previously reported that a cyclometalated iridium (Ir) complex-peptide hybrid (IPH) 4
functionalized with a cationic KKKGG peptide unit on the 2-phenylpyridine ligand induces …

Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics

LCC Lee, KKW Lo - Small Methods, 2024 - Wiley Online Library
Despite the advent of various medical interventions for cancer treatment, the disease
continues to pose a formidable global health challenge, necessitating the development of …