As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum
Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the …

Sarcopenia is a debilitating skeletal muscle disease that accelerates in the last decades of
life and is characterized by marked deficits in muscle strength, mass, quality, and metabolic …

Background Oxidative stress and damage are associated with a number of ageing
phenotypes, including age‐related loss of muscle mass and reduced contractile function …

Neuronal oxidative stress has been implicated in aging and neurodegenerative disease.
Here we investigated the impact of elevated oxidative stress induced in mouse spinal cord …

Muscle weakness associated with sarcopenia is a major contributor to reduced health span
and quality of life in the elderly. However, the underlying mechanisms of muscle weakness …

Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder characterized by
progressive muscular weakness because of the loss of dystrophin. Extracellular Ca2+ flows …

Loss of innervation is a key driver of age associated muscle atrophy and weakness
(sarcopenia). Our laboratory has previously shown that denervation induced atrophy is …

The mammalian neuromuscular junction (NMJ) comprises a presynaptic terminal, a
postsynaptic receptor region on the muscle fiber (endplate), and the perisynaptic (terminal) …

Background: Sarcopenia is a critical finding in patients with chronic heart failure (CHF).
However, the search for a definitive biomarker to predict muscle and functional decline in …

A decrease in skeletal muscle contractile activity or its complete cessation (muscle
unloading or disuse) leads to muscle fibers' atrophy and to alterations in muscle …