Anemia affects a third of the world's population and contributes to increased morbidity and
mortality, decreased work productivity, and impaired neurological development …

Sickle cell disease (SCD) is a monogenetic disorder due to a single base-pair point mutation
in the β-globin gene resulting in the substitution of the amino acid valine for glutamic acid in …

New treatments directly targeting polymerization of sickle hemoglobin (HbS), the proximate
event in the pathophysiology of sickle cell disease (SCD), are needed to address the severe …

Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is a
congenital blood disorder characterized by considerable phenotypic diversity. It comprises a …

Aims Voxelotor (previously GBT440) is a haemoglobin (Hb) modulator that increases Hb‐
oxygen affinity, thereby reducing Hb polymerization and sickling of red blood cells (RBCs) …

Background: Sickle cell disease, the inherited blood disorder characterized by anemia,
severe pain and other vaso-occlusive complications, acute chest syndrome …

Background Sickle cell disease is one of the commonest severe monogenic disorders in the
world, due to the inheritance of two abnormal haemoglobin (beta globin) genes. Sickle cell …

ABSTRACT Introduction: Sickle Cell Disease (SCD) affects 100,000 Americans and more
than 14 million people globally, mostly in economically disadvantaged populations, and …

Sickle cell disease (SCD; ORPHA232; OMIM# 603903) is a chronic and invalidating
disorder distributed worldwide, with high morbidity and mortality. Given the disease …

Guidelines include recommendations intended to optimize patient care; used appropriately,
they make healthcare consistent and efficient. In most lower‐middle income countries (LMIC …