The transition between epithelial and mesenchymal phenotype is emerging as a key
determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial …

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic
mutations and loss of tumor suppressors. Mounting evidence indicates that altered …

Several lines of evidence indicate that during transformation epithelial cancer cells can
acquire mesenchymal features via a process called epithelial‐to‐mesenchymal transition …

Many mammalian cancer cell lines depend on glutamine as a major tri-carboxylic acid (TCA)
cycle anaplerotic substrate to support proliferation. However, some cell lines that depend on …

Background Hepatocellular carcinoma (HCC) is an aggressive malignant disease with poor
prognosis. Recent advances suggest the existence of cancer stem cells (CSCs) within liver …

Tumor cells display fundamental changes in metabolism and nutrient uptake in order to
utilize additional nutrient sources to meet their enhanced bioenergetic requirements …

Activation of epithelial–mesenchymal transition (EMT) is thought to be an essential step for
cancer metastasis. Tumor cells undergo EMT in response to a diverse range of extra-and …

Cancers have an altered metabolism, and there is interest in understanding precisely how
oncogenic transformation alters cellular metabolism and how these metabolic alterations …

Amplification and overexpression of the MYC oncogene in tumor cells, including ovarian
cancer cells, correlates with poor responses to chemotherapy. As MYC is not directly …

Cancer is a complex disease of multiple alterations occuring at the epigenomic, genomic,
transcriptomic, proteomic and/or metabolic levels. The contribution of genetic mutations in …