Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

Wound healing is one of the most complex processes in the human body. It involves the
spatial and temporal synchronization of a variety of cell types with distinct roles in the …

Fibroblasts synthesize the extracellular matrix of connective tissue and play an essential role
in maintaining the structural integrity of most tissues. Researchers have long suspected that …

Tissue repair is critical for animal survival. The skin epidermis is particularly exposed to
injuries, which necessitates rapid repair. The coordinated action of distinct epidermal stem …

Previous studies have shown that mouse dermis is composed of functionally distinct
fibroblast lineages. To explore the extent of fibroblast heterogeneity in human skin, we used …

Skin homeostasis is orchestrated by dozens of cell types that together direct stem cell
renewal, lineage commitment, and differentiation. Here, we use single-cell RNA sequencing …

There are many studies on certain skin cell specifications and their contribution to wound
healing. In this review, we provide an overview of dermal cell heterogeneity and their …

Fibroblasts produce matrix, regulate inflammation, mediate reparative processes, and serve
as pluripotent mesenchymal cells. Analyzing digested normal human skin by single-cell …

Mammalian wounds typically heal by fibrotic repair without hair follicle (HF) regeneration.
Fibrosis and regeneration are currently considered the opposite end of wound healing. This …

Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by
large amounts of extracellular matrix, which may lead to organ dysfunction and even death …