The life of eukaryotic cells requires the transport of lipids between membranes, which are
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …

Parkinson's disease (PD), a neurodegenerative disorder characterized by distinct aging-
independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region …

The prevalence of Parkinson's disease (PD) is increasing but the development of novel
treatment strategies and therapeutics altering the course of the disease would benefit from …

Auxilin participates in the uncoating of clathrin-coated vesicles (CCVs), thereby facilitating
synaptic vesicle (SV) regeneration at presynaptic sites. Auxilin (DNAJC6/PARK19) loss-of …

The Endoplasmic Reticulum (ER) is an endomembrane system that plays a multiplicity of
roles in cell physiology and populates even the most distal cell compartments, including …

Parkinson's disease (PD) is a progressive neurodegenerative disorder resulting from the
death of dopamine neurons in the substantia nigra pars compacta. Our understanding of PD …

Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive
death of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies …

Mutations in VPS13C cause early-onset, autosomal recessive Parkinson's disease (PD). We
have established that VPS13C encodes a lipid transfer protein localized to contact sites …

Point mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of
familial Parkinson's disease (PD) and are implicated in a significant proportion of apparently …

Autophagy is a cellular degradation pathway essential for neuronal health and function.
Autophagosome biogenesis occurs at synapses, is locally regulated, and increases in …