Abnormal microvascular perfusion, including decreased functional capillary density and
increased blood flow heterogeneity, is observed in early stages of the systemic inflammatory …

The dorsal skinfold chamber is a rodent model for noninvasive microcirculatory analyses of
striated muscle and skin tissue throughout an observation period of 2-3 weeks. In …

Aim To investigate the efficacy of zinc oxide nanoparticles (ZnO-NPs) and/or milrinone (MIL)
on renal ischemia/reperfusion injury (I/RI) in rats and their possible underlying mechanisms …

Abnormal peripheral perfusion (PP) worsens the prognosis of patients with septic shock.
Polymyxin B-direct hemoperfusion (PMX-DHP) increases blood pressure and reduces …

Sepsis remains a major cause of morbidity and mortality among children worldwide.
Furthermore, refractory septic shock and multiple organ dysfunction syndrome are the most …

Circulatory shock is associated with marked disturbances of the macro-and microcirculation
and flow heterogeneities. Furthermore, a lack of tissue adenosine trisphosphate (ATP) and …

In the mammalian cardiovascular system, endothelial glycocalyx is a gel-like layer that
covers the luminal surface of endothelial cells (ECs) and plays crucial roles in vascular …

Septic shock involves a complex interaction between abnormal vasodilation, relative and/or
absolute hypovolemia, myocardial dysfunction, and altered blood flow distribution to the …

Background: Experimental data suggest that ivabradine, an inhibitor of the pacemaker
current in sinoatrial node, exerts beneficial effects on endothelial cell function, but it is …

BACKGROUND: Chronic venous disease of the lower limbs is a common public health
problem worldwide with negative impact on quality of life and results with drugs used to treat …