Secreted frizzled related proteins: Implications in cancers

R Surana, S Sikka, W Cai, EM Shin, SR Warrier… - … et Biophysica Acta (BBA …, 2014 - Elsevier
The Wnt (wingless-type) signaling pathway plays an important role in embryonic
development, tissue homeostasis, and tumor progression becaluse of its effect on cell …

Use of preclinical models for malignant pleural mesothelioma

M Shamseddin, J Obacz, MJ Garnett, RC Rintoul… - Thorax, 2021 - thorax.bmj.com
Malignant pleural mesothelioma (MPM) is an aggressive cancer most commonly caused by
prior exposure to asbestos. Median survival is 12–18 months, since surgery is ineffective …

Trefoil factor-1 (TFF1) enhances oncogenicity of mammary carcinoma cells

N Amiry, X Kong, N Muniraj, N Kannan… - …, 2009 - academic.oup.com
The functional role of autocrine trefoil factor-1 (TFF1) in mammary carcinoma has not been
previously elucidated. Herein, we demonstrate that forced expression of TFF1 in mammary …

A polysome-based microRNA screen identifies miR-24-3p as a novel promigratory miRNA in mesothelioma

S Oliveto, R Alfieri, A Miluzio, A Scagliola, RS Secli… - Cancer research, 2018 - AACR
The expression of miRNAs in cancer has been widely studied and has allowed the definition
of oncomirs and oncosuppressors. We note that it is often underestimated that many mRNAs …

Epigallocatechin‐3‐gallate induces mesothelioma cell death via H2O2−dependent T‐type Ca2+ channel opening

E Ranzato, S Martinotti, V Magnelli… - Journal of Cellular …, 2012 - Wiley Online Library
Malignant mesothelioma (MMe) is a highly aggressive, lethal tumour requiring the
development of more effective therapies. The green tea polyphenol epigallocathechin‐3 …

Selective ascorbate toxicity in malignant mesothelioma: a redox Trojan mechanism

E Ranzato, S Biffo, B Burlando - American journal of respiratory cell …, 2011 - atsjournals.org
We studied the mechanism of ascorbate toxicity in malignant mesothelioma (MMe) cells.
Neutral red uptake showed that ascorbate, but not dehydroascorbate, was highly toxic in the …

Biological activity of a series of cisplatin-based aliphatic bis (carboxylato) Pt (IV) prodrugs: how long the organic chain should be?

I Zanellato, I Bonarrigo, D Colangelo, E Gabano… - Journal of inorganic …, 2014 - Elsevier
The biological properties of a series of cisplatin-based Pt (IV) prodrug candidates, namely
trans, cis, cis-[Pt (carboxylato) 2 Cl 2 (NH 3) 2], where carboxylato= CH 3 (CH 2) n COO−[(1) …

Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma

C Riganti, S Orecchia, G Pescarmona… - … journal of cancer, 2006 - Wiley Online Library
Human malignant mesothelioma (HMM) is resistant to many anticancer drugs, including
doxorubicin. Mevastatin and simvastatin, 2 inhibitors of 3‐hydroxy‐3‐methylglutaryl …

The combination of sorafenib and everolimus shows antitumor activity in preclinical models of malignant pleural mesothelioma

Y Pignochino, C Dell'Aglio, S Inghilleri, M Zorzetto… - BMC cancer, 2015 - Springer
Abstract Background Malignant Pleural Mesothelioma (MPM) is an aggressive tumor arising
from mesothelial cells lining the pleural cavities characterized by resistance to standard …

Ten cases of feline mesothelioma: an immunohistochemical and ultrastructural study

B Bacci, F Morandi, M De Meo, PS Marcato - Journal of comparative …, 2006 - Elsevier
In the cat only 10 cases of mesothelioma, mainly of the peritoneum, have been previously
reported. This paper describes a further 10 cases, eight pleural and two peritoneal, in males …