Soft biological materials and their impact on cell function

I Levental, PC Georges, PA Janmey - Soft Matter, 2007 - pubs.rsc.org
Most organs and biological tissues are soft viscoelastic materials with elastic moduli ranging
from on the order of 100 Pa for the brain to 100 000 Pa for soft cartilage. Biocompatible …

Biomechanics of the lung parenchyma: critical roles of collagen and mechanical forces

B Suki, S Ito, D Stamenovic… - Journal of applied …, 2005 - journals.physiology.org
The biomechanical properties of connective tissues play fundamental roles in how
mechanical interactions of the body with its environment produce physical forces at the …

Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells

N Wang, IM Tolic-Nørrelykke, J Chen… - … of Physiology-Cell …, 2002 - journals.physiology.org
The tensegrity hypothesis holds that the cytoskeleton is a structure whose shape is
stabilized predominantly by the tensile stresses borne by filamentous structures …

[HTML][HTML] Lung parenchymal mechanics

B Suki, D Stamenovic, R Hubmayr - Comprehensive Physiology, 2011 - ncbi.nlm.nih.gov
The lung parenchyma comprises a large number of thin-walled alveoli, forming an
enormous surface area, which serves to maintain proper gas exchange. The alveoli are held …

Role of strain rate in the pathogenesis of ventilator-induced lung edema

A Protti, T Maraffi, M Milesi, E Votta, A Santini… - Critical care …, 2016 - journals.lww.com
Objective: Lungs behave as viscoelastic polymers. Harms of mechanical ventilation could
then depend on not only amplitude (strain) but also velocity (strain rate) of lung deformation …

Mechanical interactions between collagen and proteoglycans: implications for the stability of lung tissue

FSA Cavalcante, S Ito, K Brewer… - Journal of applied …, 2005 - journals.physiology.org
Collagen and elastin are thought to dominate the elasticity of the connective tissue including
lung parenchyma. The glycosaminoglycans on the proteoglycans may also play a role …

Lung parenchymal mechanics in health and disease

DS Faffe, WA Zin - Physiological reviews, 2009 - journals.physiology.org
The mechanical properties of lung tissue are important determinants of lung physiological
functions. The connective tissue is composed mainly of cells and extracellular matrix, where …

Extracellular matrix mechanics in lung parenchymal diseases

B Suki, JHT Bates - Respiratory physiology & neurobiology, 2008 - Elsevier
In this review, we examine how the extracellular matrix (ECM) of the lung contributes to the
overall mechanical properties of the parenchyma, and how these properties change in …

Lung tissue mechanics as an emergent phenomenon

B Suki, JHT Bates - Journal of applied physiology, 2011 - journals.physiology.org
The mechanical properties of lung parenchymal tissue are both elastic and dissipative, as
well as being highly nonlinear. These properties cannot be fully understood, however, in …

Friction in airway smooth muscle: mechanism, latch, and implications in asthma

JJ Fredberg, KA Jones, M Nathan… - Journal of applied …, 1996 - journals.physiology.org
Fredberg, JJ, KA Jones, M. Nathan, S. Raboudi, YS Prakash, SA Shore, JP Butler, and GC
Sieck. Friction in airway smooth muscle: mechanism, latch, and implications in asthma. J …