Fungal pathogens cause more than a billion human infections every year, resulting in more
than 1.6 million deaths annually. Understanding the natural history and evolutionary ecology …

Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

Background Emerging fungal pathogens pose important threats to global public health. The
World Health Organization has responded to the rising threat of traditionally neglected …

Mutations are the source of genetic variation and the substrate for evolution. Genome-wide
mutation rates appear to be affected by selection and are probably adaptive. Mutation rates …

Fungal infections are a global concern and the evolution of intrinsic resistance to current
antifungals presents an alarming problem. For Cryptococcus neoformans, a human fungal …

Human pathogenic fungi pose a serious threat to human health and safety. Unfortunately,
the limited number of antifungal options is exacerbated by the continuous emergence of …

We recently reported transposon mutagenesis as a significant driver of spontaneous
mutations in the human fungal pathogen Cryptococcus deneoformans during murine …

Fungi are key components in global biogeochemical cycles, play important roles in
manufacturing industries and biomedical research, and influence humans through their …

Transposable elements (TEs) spread in genomes through self-copying mechanisms and are
a major cause of genome expansions. Plant pathogens have finely tuned the expression of …

Cryptococcus neoformans infections cause approximately 15% of AIDS-related deaths
owing to a combination of limited antifungal therapies and drug resistance. A collection of …