RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …

Pseudouridine (Ψ) is the most abundant of> 150 nucleoside modifications in RNA. Although
Ψ was discovered as the first modified nucleoside more than half a century ago, neither the …

Here we studied plasma metabolomic profiles as determinants of progression to end-stage
renal disease (ESRD) in patients with type 2 diabetes (T2D). This nested case–control study …

As a crucial factor of their therapeutic efficacy, the currently marketed mRNA vaccines
feature uniform substitution of uridine (U) by the corresponding C-nucleoside, pseudouridine …

Highlights•Newly discovered enzymes possessing C-nucleoside synthase activity for
biocatalysis.•Multistep cascade reactions involving up to nine enzymes.•One-pot synthesis …

Small-molecule glycosides that exhibit a β-d-ribosyl residue linked to an aglycone via a
noncanonical C-glycosidic linkage are of great biological importance. They occur naturally …

Oxazinomycin is a C-nucleoside natural product with antibacterial and antitumor activities. In
addition to the characteristic C-glycosidic linkage shared with other C-nucleosides …

C-Analogues of the canonical N-nucleosides have considerable importance in medicinal
chemistry and are promising building blocks of xenobiotic nucleic acids (XNA) in synthetic …

Pseudouridine (Ψ) is a frequent nucleoside modification that occurs in both noncoding
RNAs and mRNAs. In pseudouridine, C5 of uracil is attached to the Rib via an unusual C …

Nucleoside antibiotics are a large class of pharmaceutically relevant chemical entities,
which exhibit a broad spectrum of biological activities. Most nucleosides belong to the …