The chromosome 21 kinase DYRK1A: emerging roles in cancer biology and potential as a therapeutic target
M Rammohan, E Harris, RS Bhansali, E Zhao, LS Li… - Oncogene, 2022 - nature.com
Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a
serine/threonine kinase that belongs to the DYRK family of proteins, a subgroup of the …
serine/threonine kinase that belongs to the DYRK family of proteins, a subgroup of the …
[HTML][HTML] The DYRK family of kinases in cancer: molecular functions and therapeutic opportunities
DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …
Azaindole derivatives as potential kinase inhibitors and their SARs elucidation
G Fang, H Chen, Z Cheng, Z Tang, Y Wan - European Journal of Medicinal …, 2023 - Elsevier
Currently, heterocycles have occupied an important position in the fields of drug design.
Among them, azaindole moiety is regarded as one privileged scaffold to develop therapeutic …
Among them, azaindole moiety is regarded as one privileged scaffold to develop therapeutic …
DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications
Protein kinases are one of the most studied drug targets in current pharmacological
research, as evidenced by the vast number of kinase-targeting agents enrolled in active …
research, as evidenced by the vast number of kinase-targeting agents enrolled in active …
LncRNA OIP5-AS1 regulates radioresistance by targeting DYRK1A through miR-369-3p in colorectal cancer cells
Y Zou, S Yao, X Chen, D Liu, J Wang, X Yuan… - European journal of cell …, 2018 - Elsevier
Object This study aimed to investigate the role of lncRNA OIP5-AS1 in regulating
radioresistance of colorectal cancer (CRC) cells. Methods Microarray analysis was used to …
radioresistance of colorectal cancer (CRC) cells. Methods Microarray analysis was used to …
DYRK1A: a down syndrome-related dual protein kinase with a versatile role in tumorigenesis
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a dual kinase
that can phosphorylate its own activation loop on tyrosine residue and phosphorylate its …
that can phosphorylate its own activation loop on tyrosine residue and phosphorylate its …
Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability
K Iwai, M Yaguchi, K Nishimura… - EMBO molecular …, 2018 - embopress.org
The modulation of pre‐mRNA splicing is proposed as an attractive anti‐neoplastic strategy,
especially for the cancers that exhibit aberrant pre‐mRNA splicing. Here, we discovered that …
especially for the cancers that exhibit aberrant pre‐mRNA splicing. Here, we discovered that …
DYRK1A modulates c-MET in pancreatic ductal adenocarcinoma to drive tumour growth
J Luna, J Boni, M Cuatrecasas, X Bofill-De Ros… - Gut, 2019 - gut.bmj.com
Background and aims Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive
tumour with a poor prognosis using current treatments. Targeted therapies may offer a new …
tumour with a poor prognosis using current treatments. Targeted therapies may offer a new …
Ablation of miR-10b suppresses oncogene-induced mammary tumorigenesis and metastasis and reactivates tumor-suppressive pathways
The invasive and metastatic properties of many human tumors have been associated with
upregulation of the miRNA miR-10b, but its functional contributions in this setting have not …
upregulation of the miRNA miR-10b, but its functional contributions in this setting have not …
[HTML][HTML] Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells
Both tumour suppressive and oncogenic functions have been reported for dual-specificity
tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed …
tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed …