Around 10% to 16% 1–4 of all individuals with colorectal cancer have a pathogenic variant
in a cancer susceptibility gene (Table 1). While not all of these genes have been associated …

Simple Summary Carriers of Lynch syndrome (LS) have an increased risk for several types
of tumour, in particular bowel and uterine cancers. LS is caused by inheritance of a faulty …

Background Standard screening of endometrial cancer (EC) for Lynch syndrome (LS) is
gaining traction; however, the prognostic impact of an underlying hereditary etiology is …

Routine screening of tumors for DNA mismatch repair (MMR) deficiency (dMMR) in
colorectal (CRC), endometrial (EC) and sebaceous skin (SST) tumors leads to a significant …

Identifying individuals who have Lynch syndrome involves a complex diagnostic workup that
includes taking a detailed family history and a combination of various tests such as …

Mismatch repair deficiency (dMMR) predicts response to immune checkpoint inhibitor
therapy in solid tumors. Long mononucleotide repeat (LMR) markers may improve the …

Universal tumor screening in endometrial carcinoma (EC) is increasingly adopted to identify
individuals at risk of Lynch syndrome (LS). These cases involve mismatch repair-deficient …

Lay Summary Endometrial cancer is common, and a subset recurs and requires additional
treatment. Some of these are recognized as being susceptible to immune therapies and are …

Objective Many patients treated with immune checkpoint inhibitors (ICIs) developed primary
or secondary drug resistance for unknown reasons. This study investigates whether …

This study aimed to compare the concordance and interchangeability of the Dako/Agilent
and Ventana/Roche mismatch repair (MMR) immunohistochemistry (IHC) assays commonly …