Experimental models of traumatic brain injury: do we really need to build a better mousetrap?

DM Morales, N Marklund, D Lebold, HJ Thompson… - Neuroscience, 2005 - Elsevier
Approximately 4000 human beings experience a traumatic brain injury each day in the
United States ranging in severity from mild to fatal. Improvements in initial management …

The potential for animal models to provide insight into mild traumatic brain injury: translational challenges and strategies

SR Shultz, SJ McDonald, CV Haar, A Meconi… - Neuroscience & …, 2017 - Elsevier
Mild traumatic brain injury (mTBI) is a common health problem. There is tremendous
variability and heterogeneity in human mTBI, including mechanisms of injury, biomechanical …

Effects of hypoxia, hyperoxia, and hypercapnia on baseline and stimulus-evoked BOLD, CBF, and CMRO2 in spontaneously breathing animals

KM Sicard, TQ Duong - Neuroimage, 2005 - Elsevier
Functional magnetic resonance imaging (fMRI) was used to investigate the effects of
inspired hypoxic, hyperoxic, and hypercapnic gases on baseline and stimulus-evoked …

Regional cerebral blood flow and BOLD responses in conscious and anesthetized rats under basal and hypercapnic conditions: implications for functional MRI studies

K Sicard, Q Shen, ME Brevard… - Journal of Cerebral …, 2003 - journals.sagepub.com
Anesthetics, widely used in magnetic resonance imaging (MRI) studies to avoid movement
artifacts, could have profound effects on cerebral blood flow (CBF) and cerebrovascular …

MR microscopy and high resolution small animal MRI: applications in neuroscience research

H Benveniste, S Blackband - Progress in neurobiology, 2002 - Elsevier
The application of magnetic resonance (MR) imaging in the study of human disease using
small animals has steadily evolved over the past two decades and strongly established the …

Neuroprotective gases–fantasy or reality for clinical use?

J Deng, C Lei, Y Chen, Z Fang, Q Yang, H Zhang… - Progress in …, 2014 - Elsevier
The neuroprotective properties for certain medical gases have been observed for decades,
leading to extensive research that has been widely reported and continues to garner …

Specificity of stimulus-evoked fMRI responses in the mouse: the influence of systemic physiological changes associated with innocuous stimulation under four different …

A Schroeter, F Schlegel, A Seuwen, J Grandjean… - Neuroimage, 2014 - Elsevier
Functional magnetic resonance (fMRI) in mice has become an attractive tool for mechanistic
studies, for characterizing models of human disease, and for evaluation of novel therapies …

Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats

KD Statler, H Alexander, V Vagni, CE Dixon… - Journal of …, 2006 - liebertpub.com
Isoflurane is commonly used in experimental traumatic brain injury (TBI), both before and
early after injury, yet it is rarely used clinically. Narcotics and benzodiazepines are frequently …

Contemporary animal models of cardiac arrest: a systematic review

M Vognsen, BK Fabian-Jessing, N Secher, B Løfgren… - Resuscitation, 2017 - Elsevier
Aim of the study Animal models are widely used in cardiac arrest research. This systematic
review aimed to provide an overview of contemporary animal models of cardiac arrest …

Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury

KD Statler, H Alexander, V Vagni, R Holubkov… - Brain research, 2006 - Elsevier
Isoflurane improves outcome vs. fentanyl anesthesia, in experimental traumatic brain injury
(TBI). We assessed the temporal profile of isoflurane neuroprotection and tested whether …