[HTML][HTML] Cytokines Focus: GM-CSF in inflammation

JA Hamilton - The Journal of experimental medicine, 2020 - ncbi.nlm.nih.gov
Granulocyte–macrophage colony-stimulating factor (GM-CSF) has many more functions
than its original in vitro identification as an inducer of granulocyte and macrophage …

[HTML][HTML] GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches

FM Lang, KMC Lee, JR Teijaro, B Becher… - Nature Reviews …, 2020 - nature.com
Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed.
Granulocyte–macrophage colony-stimulating factor (GM-CSF), a myelopoietic growth factor …

Current concepts and advances in graft-versus-host disease immunology

GR Hill, BC Betts, V Tkachev, LS Kean… - Annual review of …, 2021 - annualreviews.org
Worldwide, each year over 30,000 patients undergo an allogeneic hema-topoietic stem cell
transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency …

[HTML][HTML] Advancing cell-based cancer immunotherapy through stem cell engineering

YR Li, ZS Dunn, Y Yu, M Li, P Wang, L Yang - Cell Stem Cell, 2023 - cell.com
Advances in cell-based therapy, particularly CAR-T cell therapy, have transformed the
treatment of hematological malignancies. Although an important step forward for the field …

[HTML][HTML] Met-Flow, a strategy for single-cell metabolic analysis highlights dynamic changes in immune subpopulations

PJ Ahl, RA Hopkins, WW Xiang, B Au… - Communications …, 2020 - nature.com
A complex interaction of anabolic and catabolic metabolism underpins the ability of
leukocytes to mount an immune response. Their capacity to respond to changing …

[HTML][HTML] New approaches for the treatment of chronic graft-versus-host disease: current status and future directions

NEB Saidu, C Bonini, A Dickinson, M Grce… - Frontiers in …, 2020 - frontiersin.org
Chronic graft-versus-host disease (cGvHD) is a severe complication of allogeneic
hematopoietic stem cell transplantation that affects various organs leading to a reduced …

Transcription factor Bhlhe40 in immunity and autoimmunity

ME Cook, NN Jarjour, CC Lin, BT Edelson - Trends in immunology, 2020 - cell.com
The basic helix-loop-helix transcription factor (TF) Bhlhe40 is emerging as a key regulator of
immunity during infection, autoimmunity, and inflammatory conditions. We describe the roles …

GM-CSF: a promising target in inflammation and autoimmunity

KMC Lee, AA Achuthan, JA Hamilton - ImmunoTargets and therapy, 2020 - Taylor & Francis
The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly
identified as being able to induce in vitro the proliferation and differentiation of bone marrow …

[HTML][HTML] The role of GM-CSF autoantibodies in infection and autoimmune pulmonary alveolar proteinosis: a concise review

A Ataya, V Knight, BC Carey, E Lee, EJ Tarling… - Frontiers in …, 2021 - frontiersin.org
Autoantibodies to multiple cytokines have been identified and some, including antibodies
against granulocyte-macrophage colony-stimulating factor (GM-CSF), have been associated …

A deep dive into UV-based phototherapy: Mechanisms of action and emerging molecular targets in inflammation and cancer

PA Vieyra-Garcia, P Wolf - Pharmacology & therapeutics, 2021 - Elsevier
UV-based phototherapy (including psoralen plus UVA (PUVA), UVB and UVA1) has a long,
successful history in the management of numerous cutaneous disorders. Photoresponsive …