Type 1 diabetes is an autoimmune disorder in which the immune system attacks and
destroys insulin-producing islet cells of the pancreas. Although islet transplantation has …

In the past two decades, many polymers have been proposed for producing
immunoprotective capsules. Examples include the natural polymers alginate, agarose …

The foreign body response is an immune-mediated reaction that can lead to the failure of
implanted medical devices and discomfort for the recipient,,,,,. There is a critical need for …

Screening implantable biomaterials for antifibrotic properties is constrained by the need for
in vivo testing. Here we show that the throughput of in vivo screening can be increased by …

Islets encapsulated in immunoprotective microcapsules are being proposed as an
alternative for insulin therapy for treatment of type 1 diabetes. Many materials for producing …

Alginates comprise a unique–and at the same time-diverse family of polysaccharides that
allows fabrication of a variety of biomaterials suitable for tissue engineering. This is reflected …

The role of endogenous bile acids as lipid stabilizers aiding uptake of lipophilic nutrients via
micelle formation and saponification effects is well documented and precedes their growing …

Peptide coupled alginates obtained by chemical functionalization of alginates are commonly
used as scaffold materials for cells in regenerative medicine and tissue engineering. We …

The development of cell microencapsulation systems began several decades ago. However,
today few systems have been tested in clinical trials. For this reason, in the last years …

Transplantation of pancreatic islets in immune protective capsules holds the promise as a
functional cure for type 1 diabetes, also about 40 years after the first proof of principal study …