Clinical advances in TNC delivery vectors and their conjugate agents

W Chen, Y Wu, J Wang, W Yu, X Shen, K Zhao… - Pharmacology & …, 2023 - Elsevier
Tenascin C (TNC), a glycoprotein that is abundant in the tumor extracellular matrix (ECM), is
strongly overexpressed in tumor tissues but virtually undetectable in most normal tissues …

The nano-revolution in the diagnosis and treatment of endometriosis

C Volpini, N Bloise, M Dominoni, F Barra, VG Vellone… - Nanoscale, 2023 - pubs.rsc.org
Endometriosis is a painful gynecological disease with a high prevalence, affecting millions
of women worldwide. Innovative, non-invasive treatments, and new patient follow-up …

[HTML][HTML] The role of TNC in atherosclerosis and drug development opportunities

W Chen, Y Wang, C Ren, S Yu, C Wang… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Tenascin C (TNC), a rich glycoprotein of the extracellular matrix, exhibits a pro-
atherosclerosis or anti-atherosclerosis effect depending on its location. TNC, especially its C …

Nanoparticles traversing the extracellular matrix induce biophysical perturbation of fibronectin depicted by surface chemistry

X Guo, L Yang, C Deng, L Ren, S Li, X Zhang, J Zhao… - Nanoscale, 2024 - pubs.rsc.org
While the filtering and accumulation effects of the extracellular matrix (ECM) on
nanoparticles (NPs) have been experimentally observed, the detailed interactions between …

Homing peptide-based targeting of tenascin-C and fibronectin in endometriosis

L Simón-Gracia, K Kiisholts, V Petrikaitė, A Tobi… - Nanomaterials, 2021 - mdpi.com
The current diagnostic and therapeutic strategies for endometriosis are limited. Although
endometriosis is a benign condition, some of its traits, such as increased cell invasion …

In Vitro Study of Tumor-Homing Peptide-Modified Magnetic Nanoparticles for Magnetic Hyperthermia

S Zhou, K Tsutsumiuchi, R Imai, Y Miki, A Kondo… - Molecules, 2024 - mdpi.com
Cancer cells have higher heat sensitivity compared to normal cells; therefore, hyperthermia
is a promising approach for cancer therapy because of its ability to selectively kill cancer …

CPP Functionalized Nanoparticles

Ü Langel - CPP, Cell-Penetrating Peptides, 2023 - Springer
In this chapter, the delivery of biomolecules such as oligonucleotides, proteins, peptides and
others by connection of the power of modern nanoparticles with the flexibility and efficacy of …

Editorial on special issue “precision delivery of drugs and imaging agents with peptides”

K Kurrikoff, T Teesalu - Pharmaceutics, 2022 - mdpi.com
Homing peptides and cell-penetrating peptides allow for systemic targeting of diseased
tissues and/or efficient intracellular delivery of payloads. The translational potential of …

Targeting the tumor microenvironment: a click chemistry-based surface-functionalization method and a therapeutic-loading strategy for plasma-and erythrocyte …

MC Ciferri - 2024 - tesidottorato.depositolegale.it
Thanks to their role in intercellular communication and their natural ability to transport
functional cargoes, extracellular vesicles (EVs) have been recently considered valuable …

Main methods and tools for peptide development based on protein-protein interactions (PPIs)

J Baeza, P Cruz, P Ojeda, F Adasme-Carreño… - 2024 - chemrxiv.org
Protein-protein interactions (PPIs) regulate crucial physiological and pathological
processes. PPIs are considered a class of biological targets almost infeasible for small …