[HTML][HTML] Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review

CL Wainwright, MM Teixeira, DL Adelson… - Pharmacological …, 2022 - Elsevier
Drug discovery from natural sources is going through a renaissance, having spent many
decades in the shadow of synthetic molecule drug discovery, despite the fact that natural …

Hypericin: A natural anthraquinone as promising therapeutic agent

JJ Wu, J Zhang, CY Xia, K Ding, XX Li, XG Pan, JK Xu… - Phytomedicine, 2023 - Elsevier
Background: Hypericin is a prominent secondary metabolite mainly existing in genus
Hypericum. It has become a research focus for a quiet long time owing to its extensively …

Novel concept of exosome-like liposomes for the treatment of Alzheimer's disease

M Fernandes, I Lopes, L Magalhães, MP Sárria… - Journal of Controlled …, 2021 - Elsevier
Exosomes are cell-derived vesicles that act as carriers for proteins and nucleic acids, with
therapeutic potential and high biocompatibility. We propose a new concept of exosome-like …

Recent development in zebrafish model for bioactivity and safety evaluation of natural products

FJ Lin, H Li, DT Wu, QG Zhuang, HB Li… - Critical Reviews in …, 2022 - Taylor & Francis
The zebrafish is a species of freshwater fish, popular in aquariums and laboratories. Several
advantageous features have facilitated zebrafish to be extensively utilized as a valuable …

Maleimide conjugated PEGylated liposomal antibiotic to combat multi-drug resistant Escherichia coli and Klebsiella pneumoniae with enhanced wound healing …

DN Ladva, PP Selvadoss, GK Chitroda… - Scientific Reports, 2024 - nature.com
Antibiotic resistance is a significant threat, leaving us vulnerable to bacterial infections.
Novel strategies are needed to combat bacterial resistance beyond discovering new …

Highly stabilized nanocrystals delivering Ginkgolide B in protecting against the Parkinson's disease

Y Liu, W Liu, S Xiong, J Luo, Y Li, Y Zhao… - International journal of …, 2020 - Elsevier
As a major cause of neurodegeneration in the elderly, Parkinson's disease (PD) has
attracted intense research attention. PD results from a decline in the numbers of …

2D-QSAR, molecular docking and MD simulation based virtual screening of the herbal molecules against Alzheimer's disorder: an approach to predict CNS activity

A Thakur, B Sharma, A Parashar… - Journal of …, 2024 - Taylor & Francis
Acetylcholinesterase (AChE) is one of the key enzyme targets that have been used clinically
for the management of Alzheimer's Disorder (AD). Numerous reports in the literature predict …

Development of controlled delivery systems by nanoliposomes of Hypericum perforatum L. extracts

ÖE Altıntaş, SF Erdoğmuş - International Journal of Plant Based …, 2023 - ijpbp.com
Hypericum perforatum L. is a popular and widespread medicinal plant used in a wide range
of therapy, including gastrointestinal diseases, heart diseases, and skin-related diseases …

Proapoptotic effect of nanoliposomes loaded with hydroalcoholic extract of Hypericum perforatum L. in combination with curcumin on SW48 and SW1116 colorectal …

F Rezaeinejad, H Bardania, F Ghalamfarsa… - Journal of Medicinal …, 2022 - jmp.ir
Background: Colorectal cancer (CRC) continues to be a leading cause of cancer related
death in the world and approximately 70 to 75% of patients with metastatic colorectal cancer …

Uso del modelo de pez cebra como herramienta para evaluar la actividad antiinflamatoria y antioxidante de los alimentos. Revisión de literatura

C Arteaga, V Guanga, MF Marizande… - Investigación y …, 2022 - revistas.uta.edu.ec
El uso de metabolitos obtenidos de plantas que sean aptos para consumo humano requiere
de una evaluación previa para medir su efectividad y efectos adversos. Los comités de …