NEURON: a tool for neuroscientists

ML Hines, NT Carnevale - The neuroscientist, 2001 - journals.sagepub.com
NEURON is a simulation environment for models of individual neurons and networks of
neurons that are closely linked to experimental data. NEURON provides tools for …

Untangling dendrites with quantitative models

I Segev, M London - Science, 2000 - science.org
Our understanding of the function of dendrites has been greatly enriched by an inspiring
dialogue between theory and experiments. Rather than functionally ignoring dendrites …

Dendritic mechanisms underlying the coupling of the dendritic with the axonal action potential initiation zone of adult rat layer 5 pyramidal neurons

ME Larkum, JJ Zhu, B Sakmann - The Journal of physiology, 2001 - Wiley Online Library
Double, triple and quadruple whole‐cell voltage recordings were made simultaneously from
different parts of the apical dendritic arbor and the soma of adult layer 5 (L5) pyramidal …

Site Independence of EPSP Time Course Is Mediated by DendriticI h in Neocortical Pyramidal Neurons

SR Williams, GJ Stuart - Journal of neurophysiology, 2000 - journals.physiology.org
Neocortical layer 5 pyramidal neurons possess long apical dendrites that receive a
significant portion of the neurons excitatory synaptic input. Passive neuronal models indicate …

High I h Channel Density in the Distal Apical Dendrite of Layer V Pyramidal Cells Increases Bidirectional Attenuation of EPSPs

T Berger, ME Larkum… - Journal of …, 2001 - journals.physiology.org
Despite the wealth of recent research on active signal propagation along the dendrites of
layer V neocortical pyramidal neurons, there is still little known regarding the traffic of …

Compartmental models of rat cerebellar Purkinje cells based on simultaneous somatic and dendritic patch‐clamp recordings

A Roth, M Häusser - The Journal of physiology, 2001 - Wiley Online Library
1 Simultaneous dendritic and somatic patch‐clamp recordings were made from Purkinje
cells in cerebellar slices from 12‐to 21‐day‐old rats. Voltage responses to current impulses …

The effect of spatially inhomogeneous extracellular electric fields on neurons

CA Anastassiou, SM Montgomery… - Journal of …, 2010 - Soc Neuroscience
The cooperative action of neurons and glia generates electrical fields, but their effect on
individual neurons via ephaptic interactions is mostly unknown. Here, we analyze the impact …

Input-output functions of mammalian motoneurons

RK Powers, MD Binder - Reviews of physiology, biochemistry and …, 2007 - Springer
Communication between neurons can occur chemically via synaptic transmission. This
communication process begins when an invading depolarization opens voltage-gated …

Factors mediating powerful voltage attenuation along CA1 pyramidal neuron dendrites

NL Golding, TJ Mickus, Y Katz, WL Kath… - The Journal of …, 2005 - Wiley Online Library
We performed simultaneous patch‐electrode recordings from the soma and apical dendrite
of CA1 pyramidal neurons in hippocampal slices, in order to determine the degree of voltage …

Neuronal integration of synaptic input in the fluctuation-driven regime

A Kuhn, A Aertsen, S Rotter - Journal of Neuroscience, 2004 - Soc Neuroscience
During sensory stimulation, visual cortical neurons undergo massive synaptic bombardment.
This increases their input conductance, and action potentials mainly result from membrane …