Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA‐B Genotype and Abacavir Dosing
Human leukocyte antigen B (HLA‐B) is responsible for presenting peptides to immune cells
and plays a critical role in normal immune recognition of pathogens. A variant allele, HLA‐B …
and plays a critical role in normal immune recognition of pathogens. A variant allele, HLA‐B …
Cattle tick vaccines: many candidate antigens, but will a commercially viable product emerge?
FD Guerrero, RJ Miller, AAP de León - International Journal for Parasitology, 2012 - Elsevier
The cattle tick, Rhipicephalus microplus, is arguably the world's most economically important
external parasite of cattle. Sustainable cattle tick control strategies are required to maximise …
external parasite of cattle. Sustainable cattle tick control strategies are required to maximise …
[HTML][HTML] The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis
M Roederer, L Quaye, M Mangino, MH Beddall… - Cell, 2015 - cell.com
Despite recent discoveries of genetic variants associated with autoimmunity and infection,
genetic control of the human immune system during homeostasis is poorly understood. We …
genetic control of the human immune system during homeostasis is poorly understood. We …
Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept …
GE Gray, M Allen, Z Moodie, G Churchyard… - The Lancet infectious …, 2011 - thelancet.com
Summary Background The MRKAd5 HIV-1 gag/pol/nef subtype B vaccine was designed to
elicit T-cell-mediated immune responses capable of providing complete or partial protection …
elicit T-cell-mediated immune responses capable of providing complete or partial protection …
Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
The highly polymorphic human leukocyte antigen (HLA) locus encodes cell surface proteins
that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner …
that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner …
Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load
PJ McLaren, C Coulonges, I Bartha… - Proceedings of the …, 2015 - National Acad Sciences
Previous genome-wide association studies (GWAS) of HIV-1–infected populations have
been underpowered to detect common variants with moderate impact on disease outcome …
been underpowered to detect common variants with moderate impact on disease outcome …
[HTML][HTML] A review of HLA allele and SNP associations with highly prevalent infectious diseases in human populations
A Sanchez-Mazas - Swiss medical weekly, 2020 - smw.ch
Human leucocyte antigen (HLA) alleles and single nucleotide polymorphisms (SNPs) lying
in the HLA region are known to be associated with several infectious diseases among which …
in the HLA region are known to be associated with several infectious diseases among which …
Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease
S Kulkarni, Y Qi, C O'hUigin… - Proceedings of the …, 2013 - National Acad Sciences
Variation in the 3′ untranslated region (3′ UTR) of the HLA-C locus determines binding of
the microRNA Hsa-miR-148a, resulting in lower cell surface expression of alleles that bind …
the microRNA Hsa-miR-148a, resulting in lower cell surface expression of alleles that bind …
Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease
E Peprah, H Xu, F Tekola-Ayele, CD Royal - Public Health Genomics, 2015 - karger.com
Genomic research is one of the tools for elucidating the pathogenesis of diseases of global
health relevance and paving the research dimension to clinical and public health translation …
health relevance and paving the research dimension to clinical and public health translation …
The case for why africa should host COVID-19 candidate vaccine trials
JA Singh - The Journal of infectious diseases, 2020 - academic.oup.com
In response to provocative comments by 2 European clinicians and scientists, the World
Health Organization Director General has declared that Africa will not host COVID-19 …
Health Organization Director General has declared that Africa will not host COVID-19 …