Bacterial vaginosis: drivers of recurrence and challenges and opportunities in partner treatment

LA Vodstrcil, CA Muzny, EL Plummer, JD Sobel… - BMC medicine, 2021 - Springer
Bacterial vaginosis (BV) is the most common vaginal dysbiosis to affect women globally, yet
an unacceptably high proportion of women experience BV recurrence within 6 months of …

Protection and risk: male and female genital microbiota and sexually transmitted infections

S Tuddenham, J Ravel… - The Journal of Infectious …, 2021 - academic.oup.com
Unique compositional and functional features of the cervicovaginal microbiota have been
associated with protection against and risk for sexually transmitted infections (STI). In men …

A prospective, open-label pilot study of concurrent male partner treatment for bacterial vaginosis

EL Plummer, LA Vodstrcil, M Doyle, JA Danielewski… - Mbio, 2021 - Am Soc Microbiol
Up to 50% of women receiving first-line antibiotics for bacterial vaginosis (BV) experience
recurrence within 12 weeks. Evidence suggests that reinfection from an untreated regular …

How does voluntary medical male circumcision reduce HIV risk?

JL Prodger, RM Galiwango, AAR Tobian, D Park… - Current HIV/AIDS …, 2022 - Springer
Abstract Purpose of Review Voluntary medical male circumcision (VMMC) is a surgical
procedure that reduces HIV acquisition risk by almost two-thirds. However, global …

Vaginal and penile microbiome associations with herpes simplex virus type 2 in women and their male sex partners

SD Mehta, D Nandi, W Agingu, SJ Green… - The Journal of …, 2022 - academic.oup.com
Background We determined how the vaginal and penile microbiomes contribute to herpes
simplex virus type 2 (HSV-2) serostatus within sexual partnerships. Methods Microbiomes …

Longitudinal changes in the composition of the penile microbiome are associated with circumcision status, HIV and HSV-2 status, sexual practices, and female partner …

SD Mehta, D Nandi, W Agingu, SJ Green… - Frontiers in Cellular …, 2022 - frontiersin.org
Background Penile microbiome composition has been associated with HSV-2 and HIV in
men and with bacterial vaginosis (BV) and HSV-2 in female sex partners. This study sought …

Comparison between a deep-learning and a pixel-based approach for the automated quantification of HIV target cells in foreskin tissue

Z Shao, LB Buchanan, D Zuanazzi, YN Khan… - Scientific Reports, 2024 - nature.com
The availability of target cells expressing the HIV receptors CD4 and CCR5 in genital tissue
is a critical determinant of HIV susceptibility during sexual transmission. Quantification of …

Impact of antimicrobials on penile HIV susceptibility and immunology in uncircumcised men: A randomized phase 1/2 clinical trial

RM Galiwango, B Okech, DE Park, L Buchanan… - Cell Reports …, 2024 - cell.com
Within the penile microbiome, bacteria associated with seroconversion, immunology, and
cells (BASIC species) enhance HIV susceptibility in heterosexual uncircumcised men by …

The Effect of Oral and Topical Antibiotics on Foreskin Inflammation and HIV Target Cells in Ugandan Men

ZE Shao - 2022 - search.proquest.com
Penile circumcision reduces HIV susceptibility by up to 60% in men; however, many men
prefer to remain uncircumcised for personal or cultural reasons. Penile circumcision protects …