Psoriasis is a chronic inflammatory disease characterised by sharply demarcated
erythematous and scaly skin lesions accompanied by systemic manifestations. Classified by …

Psoriasis is a frequent inflammatory skin disease. Fundamental research on the
pathogenesis of psoriasis has substantially increased our understanding of skin …

The cytokine interleukin-23 (IL-23) is critical for development and maintenance of
autoimmune inflammation in nonlymphoid tissues; however, the mechanism through which …

Skin-resident CD8+ T cells include distinct interferon-γ–producing [tissue-resident memory T
type 1 (TRM1)] and interleukin-17 (IL-17)–producing (TRM17) subsets that differentially …

Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema.
It impairs patients' quality of life enormously. It has been recognized not only as a skin …

Therapeutic options for autoimmune diseases typically consist of broad and targeted
immunosuppressive agents. However, sustained clinical benefit is rarely achieved, as the …

Cellular sources of IL-23 and IL-17A driving skin inflammation in psoriasis remain unclear.
Using high-dimensional unsupervised flow cytometry analysis, mononuclear phagocytes …

Tissue resident memory T (TRM) cells reside in peripheral, non-lymphoid tissues such as
the skin, where they act as alarm-sensor cells or cytotoxic cells. Physiologically, skin TRM …

A key challenge in psoriasis therapy is the tendency for lesions to recur in previously
affected anatomical locations after treatment discontinuation following lesion resolution …

Over the past decades, tremendous success in the treatment of psoriasis has been achieved
using biologics, such as neutralizing antibodies against TNF/TNFR, IL-23, and IL-17A/IL …