Beta-lactams remain a critical member of our antibiotic armamentarium and are among the
most commonly prescribed antibiotic classes in the inpatient setting. For these agents, the …

Pharmacokinetic and pharmacodynamic profiles of antibiotics are important in determining
effective dosing regimens. Although minimum inhibitory concentration (MIC) data reflect …

Summary Abstract The Group 1, 1β-methyl carbapenem ertapenem (Invanz®) is approved
for parenteral use in patients with complicated intra-abdominal infection (cIAI), community …

SUMMARY The World Health Organisation's 2022 AWaRe Book provides guidance for the
use of 39 antibiotics to treat 35 infections in primary healthcare and hospital facilities. We …

The effect of colistin on bacterial eradication and survival was tested in experimental
infection by multidrug-resistant Acinetobacter baumannii. The thigh infection model was …

ABSTRACT WCK 5222 is a combination of cefepime and the novel β-lactam enhancer (BLE)
zidebactam. Zidebactam has a dual mechanism of action involving high-affinity penicillin …

The purpose of this study was to examine the in vivo efficacies of meropenem and
ertapenem against extended-spectrum-β-lactamase (ESBL)-producing isolates with a wide …

Acinetobacter baumannii remains a difficult-to-treat pathogen that poses a significant
challenge to clinicians and costs to the healthcare system. There is a lack of clinical efficacy …

Ertapenem, a parenteral broad-spectrum 1-β-methyl-carbapenem, was licensed 5 years ago
for clinical practice in the US and Europe. The substance has a good in vitro activity against …

Abstract Development of new antibacterial agents is necessary as drug-resistant bacteria
are a threat to global health. In Europe, the European Medicines Agency has been guiding …