Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

Resident tissue macrophages (RTMs) have a broad spectrum of immune-and non-immune-
related tissue-supporting activities. The roots of this heterogeneity and versatility are only …

Alzheimer's disease (AD) is characterized by synaptic loss, which can result from
dysfunctional microglial phagocytosis and complement activation. However, what signals …

A key aspect of nearly all single-cell sequencing experiments is dissociation of intact tissues
into single-cell suspensions. While many protocols have been optimized for optimal cell …

Aging results in gray and white matter degeneration, but the specific microglial responses
are unknown. Using single-cell RNA sequencing from white and gray matter separately, we …

Oligodendrocyte dysfunction has been implicated in the pathogenesis of neurodegenerative
diseases, so understanding oligodendrocyte activation states would shed light on disease …

The role of microglia cells in Alzheimer's disease (AD) is well recognized, however their
molecular and functional diversity remain unclear. Here, we isolated amyloid plaque …

Microglia were first recognized as a distinct cell population in the CNS one century ago. For
a long time, they were primarily considered to be phagocytes responsible for removing …

Microglia are increasingly recognized for their major contributions during brain development
and neurodegenerative disease. It is currently unknown whether these functions are carried …

Tissue macrophages are immune cells whose phenotypes and functions are dictated by
origin and niches. However, tissues are complex environments, and macrophage …