Glutathione is a remarkably functional molecule with diverse features, which include being
an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in …

During Parkinson's disease (PD), both the central nervous system (CNS) and peripheral
nervous system (PNS) are affected. In parallel, innate immune cells respond early to …

The pathological aggregation of the presynaptic protein α-synuclein (α-syn) and propagation
through synaptically coupled neuroanatomical tracts is increasingly thought to underlie the …

Multiple system atrophy (MSA) is a fatal neurodegenerative disease characterized by
autonomic failure and motor impairment. The hallmark pathologic finding in MSA is …

Background Multiple system atrophy (MSA) is a neurodegenerative condition characterized
by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and …

Alpha-synuclein aggregates are the hallmark pathology of Parkinson's disease, which can
propagate in a stereotypical pattern along the brain-body axis. Parkinson's disease patients …

Intracellular accumulation of abnormal proteins with conformational changes is the defining
neuropathological feature of neurodegenerative diseases. The pathogenic proteins that …

Protein aggregation and amyloid formation have historically been linked with various
diseases such as Alzheimer's and Parkinson's disease, but recently functional amyloids …

Parkinson disease (PD) is a severe neurodegenerative disorder that affects around 2% of
the population over 65 years old. It is characterized by the progressive loss of nigrostriatal …

The aberrant accumulation of α-Synuclein within oligodendrocytes is an enigmatic,
pathological feature specific to Multiple system atrophy (MSA). Since the characterization of …