Metabolômica: definições, estado-da-arte e aplicações representativas
GAB Canuto, JL Costa, PLR Cruz, ARL Souza… - Química …, 2018 - SciELO Brasil
Metabolomics is an emerging and promising omics approach used to understand biological
mechanisms. By untargeted and targeted metabolomics analyses, metabolites are …
mechanisms. By untargeted and targeted metabolomics analyses, metabolites are …
Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach
Aim: COVID-19 is currently the biggest threat to mankind. Recently, ivermectin (a US FDA-
approved antiparasitic drug) has been explored as an anti-SARS-CoV-2 agent. Herein, we …
approved antiparasitic drug) has been explored as an anti-SARS-CoV-2 agent. Herein, we …
Revolution in malaria detection: unveiling current breakthroughs and tomorrow's possibilities in biomarker innovation
The ongoing battle against malaria has seen significant advancements in diagnostic
methodologies, particularly through the discovery and application of novel biomarkers …
methodologies, particularly through the discovery and application of novel biomarkers …
In silico identification of new anti-SARS-CoV-2 agents from bioactive phytocompounds targeting the viral spike glycoprotein and human TLR4
Background: The recent outbreak of novel coronavirus disease (COVID-19) pandemic
caused by SARS-CoV-2 has posed a tremendous threat to mankind. The unavailability of a …
caused by SARS-CoV-2 has posed a tremendous threat to mankind. The unavailability of a …
Reverse vaccinology assisted design of a novel multi-epitope vaccine to target Wuchereria bancrofti cystatin: An immunoinformatics approach
Proteases are the critical mediators of immunomodulation exerted by the filarial parasites to
bypass and divert host immunity. Cystatin is a small (∼ 15 kDa) immunomodulatory filarial …
bypass and divert host immunity. Cystatin is a small (∼ 15 kDa) immunomodulatory filarial …
Comparison of cytotoxicity of Miltefosine and its niosomal form on chick embryo model
Various drugs have been used for the treatment of leishmaniasis, but they often have
adverse effects on the body's organs. In this study, we aimed to explore the effects of one …
adverse effects on the body's organs. In this study, we aimed to explore the effects of one …
m1A methylation modification patterns and metabolic characteristics in hepatocellular carcinoma
C Tong, W Wang, C He - BMC gastroenterology, 2022 - Springer
Background The dysregulation of RNA methylation has been demonstrated to contribute to
tumorigenicity and progression in recent years. However, the alteration of N1 …
tumorigenicity and progression in recent years. However, the alteration of N1 …
Quinolone-fused cyclic sulfonamide as a novel benign antifilarial agent
Search of potent antifilarial drugs has been a major thrust area in tropical medicine research
over the decades. Herein, we report 4, 7-dimethyl-3, 4, 7, 8-tetrahydro-3λ6-[1, 2] thiazino [4 …
over the decades. Herein, we report 4, 7-dimethyl-3, 4, 7, 8-tetrahydro-3λ6-[1, 2] thiazino [4 …
Aryl quinolinyl hydrazone derivatives as anti-inflammatory agents that inhibit TLR4 activation in the macrophages
A series of aryl 7-chloroquinolinyl hydrazone derivatives (3a-u) have been synthesized in 55–
76% yield using simple reaction condition. The synthesized compounds were evaluated for …
76% yield using simple reaction condition. The synthesized compounds were evaluated for …
Step toward repurposing drug discovery for COVID‐19 therapeutics through in silico approach
BN Marak, J Dowarah, L Khiangte… - Drug Development …, 2021 - Wiley Online Library
The outbreak of SARS‐CoV‐2 has become a threat to global health and has led to a global
economic crisis. Although the researchers worldwide are putting tremendous effort toward …
economic crisis. Although the researchers worldwide are putting tremendous effort toward …