Hearing impairment is the most common sensory disorder, present in 1 of every 500
newborns. With 46 genes implicated in nonsyndromic hearing loss, it is also an extremely …

Gene therapy, or the treatment of human disease using genetic material, for inner ear
dysfunction is coming of age. Recent progress in developing gene therapy treatments for …

Abstract Background Copy number variants (CNVs) are a well-recognized cause of genetic
disease; however, methods for their identification are often gene-specific, excluded as …

More than 50 percent of prelingual hearing loss is genetic in origin, and of these up to 93
percent are monogenic autosomal recessive traits. Some forms of genetic deafness can be …

This article is a review of the genes and genetic disorders that affect hearing in humans and
a few selected mouse models of deafness. Genetics is playing an increasingly critical role in …

Age-related hearing loss is due to death over time, primarily by apoptosis, of hair cells in the
inner ear. Studies of mutant genes responsible for inherited progressive hearing loss have …

Hearing loss (HL) is the most prevalent sensory defect affecting 1 in 500 neonates. Genetic
factors are involved in half of the cases. The extreme heterogeneity of HL makes it difficult to …

Hearing loss is the leading sensory deficit, affecting~ 5% of the population. It exhibits
remarkable heterogeneity across 223 genes with 6328 pathogenic missense variants …

There is growing attention and effort focused on treating the root cause of sensorineural
hearing loss rather than managing associated secondary characteristic features. With recent …

Mutations in the transmembrane channel-like gene 1 (TMC1) can cause both DFNA36 and
DFNB7/11 hearing loss. More than thirty DFNB7/11 mutations have been reported, but only …