Glucocorticoid hormones were discovered to have use as potent anti-inflammatory and
immunosuppressive therapeutics in the 1940s and their continued use and development …

The term sarcopenia was first introduced in 1988 by Irwin Rosenberg to define a condition of
muscle loss that occurs in the elderly. Since then, a broader definition comprising not only …

Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …

As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

There is now overwhelming evidence to support lowering LDL-c (low-density lipoprotein
cholesterol) to reduce cardiovascular morbidity and mortality. Statins are a class of drugs …

Cancer-associated cachexia is a disorder characterized by loss of body weight with specific
losses of skeletal muscle and adipose tissue. Cachexia is driven by a variable combination …

The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …

Heart failure (HF) is considered as a severe health problem worldwide, while cardiac fibrosis
is one of the main driving factors for the progress of HF. Cardiac fibrosis was characterized …

The maintenance of mitochondrial integrity is critical for muscle health. Mitochondria,
indeed, play vital roles in a wide range of cellular processes, including energy supply, Ca2+ …