UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion
(ADME) processes of a drug. Understanding PK properties is essential for drug development …

UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …

Glucuronidation is an important metabolic pathway for many small endogenous and
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …

The purpose of this study was to generate, by real-time PCR, a quantitative expression level
profile of the 19 human UDP-glucuronosyltransferases (UGTs) of subfamilies 1A, 2A and 2B …

Metabolic disposition of drugs and other xenobiotics includes glucuronidation reactions that
are catalyzed by the uridine diphosphate glucuronosyltransferases (UGTs). The most …

Enzymes of the UDP-glucuronosyltransferase (UGT) superfamily contribute to the
elimination of drugs from almost all therapeutic classes. Awareness of the importance of …

Ten out of 19 UDP-glucuronosyltransferases (UGTs) are substantially expressed in adult
human liver (> 1% of total UGTs); 5 UGT1 isoforms (UGT1A1, 1A3, 1A4, 1A6 and 1A9) and 5 …

The human UGT gene superfamily is divided into four subfamilies (UGT1, UGT2, UGT3 and
UGT8) that encodes 22 functional enzymes. UGTs are critical for the metabolism and …

Limited understanding of drug pharmacokinetics in children is one of the major challenges
in paediatric drug development. This is most critical in neonates and infants owing to rapid …