Highlights•We discuss recent advances in understanding inflammasome formation and
regulation.•We compare the recent structure of NLRC4 to Apaf-1 and apoptosomes.•NLRC4 …

Since the discovery of Toll, in the fruit fly Drosophila melanogaster, as the first described
pattern recognition receptor (PRR) in 1996, many families of these receptors have been …

Inflammasomes sense intrinsic and extrinsic danger signals to trigger inflammatory
responses and pyroptotic cell death. Homotypic pyrin domain (PYD) interactions of …

Oocyte maturation is vital to attain full competence required for fertilization and
embryogenesis. NLRP14 is preferentially expressed in mammalian oocytes and early …

Objective (s): This study aimed to evaluate the role of the linker histone (H 1) in the binding
interaction between ambochlorin (Amb), and calf thymus DNA (ctDNA) as binary and ternary …

The NLRP3 inflammasome is a key macromolecular complex of the innate immune system
that activates the inflammatory signalling cascade in response to a wide range of stimuli …

Plant NLRs share many of the structural hallmarks of their animal counterparts. At a
functional level, the central nucleotide-binding pocket appears to have binding and …

Inflammasomes are cytosolic multimeric signaling complexes of the innate immune system
that induce activation of caspases. The NOD‐like receptor NLRP9 recruits the adaptor …

The PYRIN domain (PYD) is a protein–protein interaction domain, which belongs to the
death domain fold (DDF) superfamily. It is best known for its signaling function in innate …

Caspase-8 is an apoptotic protease that is activated by a proximity-induced dimerization
mechanism within the death-inducing signaling complex (DISC). The death effector domain …