The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …

Nicotinamide adenine dinucleotide (NAD) is an important co-factor involved in numerous
physiological processes, including metabolism, post-translational protein modification, and …

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature
aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase …

The numerous biological roles of NAD+ are organized and coordinated via its
compartmentalization within cells. The spatial and temporal partitioning of this intermediary …

In 1963, Chambon et al. reported the detection of a nicotinamide mononucleotide-activated,
DNA-dependent enzymatic activity in rat liver extracts that catalyzed the synthesis of a …

Nicotinamide adenine dinucleotide (NAD+) is an essential biomolecule involved in many
critical processes. Its role as both a driver of energy production and a signaling molecule …

The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes a
reaction central to all known NAD biosynthetic routes. In mammals, three isoforms with …

The transcription of ribosomal RNA genes (rDNA) is subject to epigenetic regulation, as it is
abrogated by the methylation of CpG dinucleotides within their promoter region. Here, we …

Mitochondrial sirtuins have diverse role specifically in aging, metabolism and cancer. In
cancer, these sirtuins play dichotomous role as tumor suppressor and promoter. Previous …

Gliomas are highly malignant brain tumors with poor prognosis and short survival. NAD+
has been shown to impact multiple processes that are dysregulated in cancer; however, anti …