Abstract The PI3K/AKT/mTOR pathway is frequently activated in various human cancers and
has been considered a promising therapeutic target. Many of the positive regulators of the …

Acinar cells in the adult pancreas show high plasticity and can undergo transdifferentiation
to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal …

Diabetes is associated with β cell failure. But it remains unclear whether the latter results
from reduced β cell number or function. FoxO1 integrates β cell proliferation with adaptive β …

The Kras gene is mutated to an oncogenic form in most pancreatic tumors. However, early
attempts to use this molecule as a specific biomarker of the disease, or inhibit its activity as a …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in
KRAS and frequent deregulation of crucial embryonic signalling pathways, including the …

Inhibitors of mechanistic target of rapamycin (mTOR inhibitors) are used as antiproliferative
immunosuppressive drugs and have many clinical applications in various drug …

Pancreatic β cells are mostly post-mitotic, but it is unclear what locks them in this state.
Perturbations including uncontrolled hyperglycemia can drive β cells into more pliable states …

Initiation of pancreatic ductal adenocarcinoma (PDAC) is driven by oncogenic KRAS
mutation, and disease progression is associated with frequent loss of tumor suppressors. In …

The federal drug administration (FDA)-approved compound rapamycin was the first
pharmacological agent shown to extend maximal lifespan in both genders in a mammalian …

Aims/hypothesis The plasticity of adult somatic cells allows for their dedifferentiation or
conversion to different cell types, although the relevance of this to disease remains elusive …