As one of the few cellular traits that can be quantified across the tree of life, DNA-replication
fidelity provides an excellent platform for understanding fundamental evolutionary …

DNA double-strand breaks (DSBs) can arise from multiple sources, including exposure to
ionizing radiation. The repair of DSBs involves both posttranslational modification of …

Since the first half of the twentieth century, evolutionary theory has been dominated by the
idea that mutations occur randomly with respect to their consequences. Here we test this …

Mutations are the source of genetic variation and the substrate for evolution. Genome-wide
mutation rates appear to be affected by selection and are probably adaptive. Mutation rates …

Although enhancers play critical roles in cancer, quantifying enhancer activities in clinical
samples remains challenging, especially for super-enhancers. Enhancer activities can be …

Large-scale chromatin features, such as replication time and accessibility influence the rate
of somatic and germline mutations at the megabase scale. This article reviews how local …

Bursts of nascent mRNA have been shown to lead to substantial cell-cell variation in
unicellular organisms, facilitating diverse responses to environmental challenges. It is …

The variation in local rates of mutations can affect both the evolution of genes and their
function in normal and cancer cells. Deciphering the molecular determinants of this variation …

Owing to advances in genome sequencing, genome stability has become one of the most
scrutinized cellular traits across the Tree of Life. Despite its centrality to all things biological …

Synonymous sites are generally assumed to be subject to weak selective constraint. For this
reason, they are often neglected as a possible source of important functional variation. We …