PKC comprises a large family of serine/threonine kinases that share a requirement for
allosteric activation by lipids. While PKC isoforms have significant homology, functional …

Protein kinase C α (PKCα) is a ubiquitously expressed member of the PKC family of
serine/threonine kinases with diverse functions in normal and neoplastic cells. Early studies …

Cyclin D1 is mainly known as an oncogenic driver in cancers, and the dysregulated cyclin
D1/cyclin-dependent kinase (CDK) 4/6 axis is considered an attractive target for cancer …

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, and
its incidence is rising because of the aging population. Nectin cell adhesion molecule 4 …

In the oil sector, a novelty in the centrifugal extraction system is represented by the multi-
phase decanters (DMF) that work without adding process water and with the advantage of …

Inactivating mutations of the tumor suppressor Adenomatosis Polyposis Coli (APC), which
are found in familial adenomatosis polyposis and in 80% of sporadic colorectal cancers …

Protein kinase C (PKC) is a multifunctional family of Ser-Thr kinases widely implicated in the
regulation of fundamental cellular functions, including proliferation, polarity, motility, and …

Cyclins are key regulators of cell cycle progression and survival. Particularly cyclins D
(cyclin D1, D2, and D3) act in response to the mitogenic stimulation and are pivotal …

Tight coordination of growth regulatory signaling is required for intestinal epithelial
homeostasis. Protein kinase C α (PKCα) and transforming growth factor β (TGFβ) are …

Nishizuka and colleagues discovered protein kinase C (PKC) as a calcium-dependent, lipid
cofactorsensitive protein kinase (1). Initially known as the only physiological effector for …