[HTML][HTML] Mitochondrial oxidative stress in aging and healthspan
The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …
[HTML][HTML] Experimental models of sarcopenia: bridging molecular mechanism and therapeutic strategy
S Mankhong, S Kim, S Moon, HB Kwak, DH Park… - Cells, 2020 - mdpi.com
Sarcopenia has been defined as a progressive decline of skeletal muscle mass, strength,
and functions in elderly people. It is accompanied by physical frailty, functional disability …
and functions in elderly people. It is accompanied by physical frailty, functional disability …
[HTML][HTML] Redox basis of exercise physiology
Redox reactions control fundamental processes of human biology. Therefore, it is safe to
assume that the responses and adaptations to exercise are, at least in part, mediated by …
assume that the responses and adaptations to exercise are, at least in part, mediated by …
Redefining the major contributors to superoxide production in contracting skeletal muscle. The role of NAD (P) H oxidases
The production of reactive oxygen and nitrogen species (RONS) by skeletal muscle is
important as it (i) underlies oxidative damage in many degenerative muscle pathologies and …
important as it (i) underlies oxidative damage in many degenerative muscle pathologies and …
[HTML][HTML] SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer
SOD1 is known as the major cytoplasmic superoxide dismutase and an anticancer target.
However, the role of SOD1 in cancer is not fully understood. Herein we describe the …
However, the role of SOD1 in cancer is not fully understood. Herein we describe the …
[HTML][HTML] Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy
Age-related loss of skeletal muscle mass and function is a major contributor to morbidity and
has a profound effect on the quality of life of older people. The potential role of age …
has a profound effect on the quality of life of older people. The potential role of age …
[HTML][HTML] Elevated hydrogen peroxide and decreased catalase and glutathione peroxidase protection are associated with aging sarcopenia
MJ Sullivan-Gunn, PA Lewandowski - BMC geriatrics, 2013 - Springer
Background Sarcopenia is the progressive loss of skeletal muscle that contributes to the
decline in physical function during aging. A higher level of oxidative stress has been …
decline in physical function during aging. A higher level of oxidative stress has been …
[HTML][HTML] Redox signaling and sarcopenia: searching for the primary suspect
Sarcopenia, the age-related decline in muscle mass and function, derives from multiple
etiological mechanisms. Accumulative research suggests that reactive oxygen species …
etiological mechanisms. Accumulative research suggests that reactive oxygen species …
Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation
H Xu, B Ahn, H Van Remmen - Science Advances, 2022 - science.org
Muscle weakness associated with sarcopenia is a major contributor to reduced health span
and quality of life in the elderly. However, the underlying mechanisms of muscle weakness …
and quality of life in the elderly. However, the underlying mechanisms of muscle weakness …
[HTML][HTML] A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse
SS Deepa, S Bhaskaran, S Espinoza, SV Brooks… - Geroscience, 2017 - Springer
Frailty is a geriatric syndrome that is an important public health problem for the older adults
living in the USA. Although several methods have been developed to measure frailty in …
living in the USA. Although several methods have been developed to measure frailty in …