Regulatory T cells (Tregs) are abundant in tumor tissues, raising a question of whether
immunosuppressive tumor-infiltrating Tregs (TI-Tregs) can be selectively depleted or …

Allergy is a Th2‐mediated disease that involves the formation of specific IgE antibodies
against innocuous environmental substances. The prevalence of allergic diseases has …

The TGF-β1 cytokine is a key mediator of many biological processes. Complex regulatory
mechanisms are in place that allow one single molecule to exert so many distinct …

The neuropilins (Nrps) are multifunctional proteins involved in development, immunity and
cancer. Neuropilin-1 (Nrp1), or its homologue neuropilin-2 (Nrp2), are coreceptors that …

The extent to which T-cell–mediated immune surveillance is impaired in human cancer
remains a question of major importance, given its potential impact on the development of …

Since its rediscovery in the mid-1990s, FOXP3+ regulatory T cells (Tregs) have climbed the
rank to become commander-in-chief of the immune system. They possess diverse power …

Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including
cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix …

Abstract Human Treg and Th clones secrete the latent form of TGF‐β, in which the mature
TGF‐β protein is bound to the latency‐associated peptide (LAP), and is thereby prevented …

Glycoprotein-A repetitions predominant protein (GARP) associates with latent transforming
growth factor-β (proTGFβ) on the surface of T regulatory cells and platelets; however …

Regulatory T cells (Tregs) are essential to prevent autoimmunity, but excessive Treg function
contributes to cancer progression by inhibiting antitumor immune responses. Tregs exert …