This work reviews nuclear compartments, defined broadly to include distinct nuclear
structures, bodies, and chromosome domains. It first summarizes original cytological …

Immediately following the discovery of the structure of DNA and the semi-conservative
replication of the parental DNA sequence into two new DNA strands, it became apparent …

Somatic mutations in driver genes may ultimately lead to the development of cancer.
Understanding how somatic mutations accumulate in cancer genomes and the underlying …

The compartmental organization of mammalian genomes and its changes play important
roles in distinct biological processes. Here, we introduce dcHiC, which utilizes a multivariate …

Faithful DNA replication is essential for genome integrity,,–. Under-replicated DNA leads to
defects in chromosome segregation, which are common during embryogenesis,,–. However …

Abstract Although three-dimensional (3D) genome organization is central to many aspects of
nuclear function, it has been difficult to measure at the single-cell level. To address this, we …

Chromosome-wide late replication is an enigmatic hallmark of the inactive X chromosome
(Xi). How it is established and what it represents remains obscure. By single-cell DNA …

SETDB1 is an essential histone methyltransferase that deposits histone H3 lysine 9
trimethylation (H3K9me3) to transcriptionally repress genes and repetitive elements. The …

DNA replication timing and three-dimensional (3D) genome organization are associated
with distinct epigenome patterns across large domains. However, whether alterations in the …

DNA replication enables genetic inheritance across the kingdoms of life. Replication occurs
with a defined temporal order known as the replication timing (RT) programme, leading to …