Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

The known seven mammalian receptor subunits (P2X1–7) form cationic channels gated by
ATP. Three subunits compose a receptor channel. Each subunit is a polypeptide consisting …

P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …

Abstract P2X receptors are ATP-activated cation channels, and the P2X4 subtype plays
important roles in the immune system and the central nervous system, particularly in …

P2X receptors are non-selective cation channels gated by extracellular ATP, and the P2X7
receptor subtype plays a crucial role in the immune and nervous systems. Altered …

Coot is a graphics application that is used to build or manipulate macromolecular models; its
particular forte is manipulation of the model at the residue level. The model-building tools of …

Within the family of purinergic receptors, the P2X1 receptor is a ligand-gated ion channel
that plays a role in urogenital, immune and cardiovascular function. Specifically, the P2X1 …

Abstract P2X receptors are ATP‐gated trimeric nonselective cation channels that are
important for various physiological and pathological processes, including synaptic …

This review article presents a collection of tool compounds that selectively block and are
recommended for studying P2Y and P2X receptor subtypes, investigating their roles in …

Overcoming refractory epilepsy's resistance to the combination of antiepileptic drugs (AED),
mitigating side effects, and preventing sudden unexpected death in epilepsy are critical …