Age-related macular degeneration, the leading cause of irreversible visual loss among older
adults in developed countries, is a chronic, multifactorial, and progressive disease with the …

Cancer cells with specific genetic alterations may be highly dependent on certain nutrients
for survival, which can inform therapeutic strategies to target these cancer-specific metabolic …

Purpose: Tumor-infiltrating lymphocytes (TIL) are strongly associated with survival in most
cancers; however, the tumor-reactive subset that drives this prognostic effect remains poorly …

Spontaneous control of human immunodeficiency virus (HIV) is generally associated with an
enhanced capacity of CD8+ T cells to eliminate infected CD4+ T cells, but the molecular …

The occurrence and progression of tumors are inseparable from glucose metabolism. With
the development of tumors, the volume increases gradually and the nutritional supply of …

The growth of glioblastoma (GBM), one of the deadliest adult cancers, is fuelled by a
subpopulation of stem/progenitor cells, which are thought to be the source of resistance and …

Glioblastoma is a highly aggressive brain tumour that creates an immunosuppressive
microenvironment. Microglia, the brain's resident immune cells, play a crucial role in this …

Background Despite advances in prognosis and treatment of lung adenocarcinoma (LADC),
a notable non–small cell lung cancer subtype, patient outcomes are still unsatisfactory. New …

Aging is associated with functional deficits in the naive T cell compartment, which
compromise the generation of de novo immune responses against previously …

Background: Cancer cells have to take metabolic transformation in tumor progression when
facing need of increased energy and adequate vascularization. However, molecular …