Histones, the fundamental packaging elements of eukaryotic DNA, are highly decorated with
a diverse set of post-translational modifications (PTMs) that are recognized to govern the …

1. INTRODUCTION In eukaryotic cells, inheritable information is stored in a nucleoprotein
complex referred to as chromatin. 1 This genome architecture serves two key purposes. On …

Access to high-quality antibodies is a necessity for the study of histones and their
posttranslational modifications (PTMs). Here we debut the Histone Antibody Specificity …

Histone post-translational modifications (PTMs) are important genomic regulators often
studied by chromatin immunoprecipitation (ChIP), whereby their locations and relative …

Post-translational modifications (PTMs) occur on nearly all proteins. Many domains within
proteins are modified on multiple amino acid sidechains by diverse enzymes to create a …

Increasing evidence suggests that histone posttranslational modifications (PTMs) function in
a combinatorial fashion to regulate the diverse activities associated with chromatin. Yet how …

Mutations in the ATRX protein are associated with the alpha-thalassemia and mental
retardation X-linked syndrome (ATR-X). Almost half of the disease-causing mutations occur …

Different combinations of histone modifications have been proposed to signal distinct gene
regulatory functions, but this area is poorly addressed by existing technologies. We applied …

SETDB1 is an essential H3K9 methyltransferase involved in silencing of retroviruses and
gene regulation. We show here that its triple Tudor domain (3TD) specifically binds to doubly …

The field of epigenomics has been transformed by chromatin immunoprecipitation
approaches that provide for the localization of a defined protein or posttranslationally …