The Hippo signaling pathway is a highly conserved signaling network for controlling organ
size, tissue homeostasis, and regeneration. It integrates a wide range of intracellular and …

Decades of research into the Hippo signaling pathway have greatly advanced our
understanding of its roles in organ growth, tissue regeneration, and tumorigenesis. The …

Rationale: Chronic kidney disease (CKD) is a global public health issue, with vascular
calcification (VC) being a common and deadly complication. Despite its prevalence, the …

Due to its essential roles in cell proliferation and apoptosis, the precise regulation of the
Hippo pathway through LATS presents a viable biological target for developing new drugs …

In a recent publication in Cell, a multidisciplinary academic drug discovery team, with its spin-
off HepaRegeniX, published a first-in-class small molecule MKK4 inhibitor (HRX215) with …

Tissue regeneration relies on the ability of cells to undergo de novo patterning. While tissue
patterning has been viewed as the transition from initially identical un-patterned cells to an …

Rheumatic immune disorders are a group of conditions that affect the immune system,
leading to various clinical symptoms. These diseases can cause pain, reduce the quality of …

Hippo-YAP signaling orchestrates epithelial tissue repair and is therefore an attractive target
in regenerative medicine. Yet it is unresolved how YAP integrates with mitogen signaling …

Hippo-YAP signaling orchestrates epithelial tissue repair and is therefore an attractive target
in regenerative medicine. Yet it is unresolved how YAP controls the underlying transient …