Major depressive disorder (MDD) is a leading cause of suicide in the world. Monoamine-
based antidepressant drugs are a primary line of treatment for this mental disorder, although …

Comorbidities are common in children with epilepsy, with nearly half of the patients having
at least one comorbidity. Attention deficit hyperactivity disorder (ADHD) is a psychiatric …

Drug-drug interactions (DDIs) arising from the perturbation of drug metabolising enzyme
activities represent both a clinical problem and a potential economic loss for the …

Importance Precise estimation of a patient's drug metabolism capacity is important for
antiseizure dose personalization. Objective To quantify the differences in plasma …

Background: With the gradual increase in prevalence in recent years, non-alcoholic
steatohepatitis (NASH) has become one of the significant health problems that urgently …

The anti-epileptic drug lamotrigine (LTG) has been widely used to treat various neurological
disorders, including epilepsy and bipolar disorder. However, its precise mechanism of action …

Background Previous studies have demonstrated that high-density lipoprotein cholesterol
(HDL-C) plays an anti-atherosclerosis role through reverse cholesterol transport. Several …

Epilepsy and migraine are both episodic disorders and share clinical as well as
pathophysiological mechanisms. The prevalence of epilepsy in migraine patients is …

Objective The present study aimed to explore the mechanisms underlying the comorbidity of
epilepsy and migraine, identify potential common targets for drug intervention, and provide …

Background Eslicarbazepine acetate (ESL), a novel sodium channel blocker, is approved for
mono and adjunctive treatment of partial epileptic seizures with or without secondary …