The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that
regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural …

Wnt signaling controls a variety of developmental and homeostatic events. As a key
component of Wnt signaling, Dishevelled (Dvl/Dsh) protein relays Wnt signals from receptors …

More is becoming known about so-called noncanonical Wnt pathways that signal
independently of β-catenin. Here we review recent developments in both the functions and …

Planar polarity describes the coordinated polarisation of cells or structures in the plane of a
tissue. The patterning mechanisms that underlie planar polarity are well characterised in …

Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the
tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP …

Contact inhibition of locomotion was discovered by Abercrombie more than 50 years ago
and describes the behaviour of fibroblast cells confronting each other in vitro, where they …

Most, if not all, cell types and tissues display several aspects of polarization. In addition to
the ubiquitous epithelial cell polarity along the apical-basolateral axis, many epithelial …

The notochord is the defining structure of the chordates, and has essential roles in
vertebrate development. It serves as a source of midline signals that pattern surrounding …

In contrast to mammals, lower vertebrates have a remarkable capacity to regenerate
complex structures damaged by injury or disease. This process, termed epimorphic …

Abstract Signalling through Frizzled (Fz)/planar cell polarity (PCP) is a conserved
mechanism that polarizes cells along specific axes in a tissue. Genetic screens in …