Toxicology, mode of action and target site-mediated resistance to insecticides acting on chloride channels

JR Bloomquist - Comparative Biochemistry and Physiology Part C …, 1993 - Elsevier
The discovery that the avermectins and cyclodienes affected the chloride channels of
excitable membranes generated intense research interest among academic and industrial …

Behavioral toxicology, risk assessment, and chlorinated hydrocarbons.

AM Evangelista de Duffard… - Environmental health …, 1996 - ehp.niehs.nih.gov
Behavioral end points are being used with greater frequency in neurotoxicology to detect
and characterize the adverse effects of chemicals on the nervous system. Behavioral …

Behavioral and monoaminergic changes after lindane exposure in developing rats

S Rivera, R Rosa, E Martínez, C Suñol… - Neurotoxicology and …, 1998 - Elsevier
The effects of lindane on behavior and central monoaminergic systems were studied in rat
pups at 15 days of postnatal age. Pups were previously given nonconvulsant lindane PO …

Reversal of propoxur-induced impairment of memory and oxidative stress by 4′-chlorodiazepam in rats

KD Mehta, GR Garg, AK Mehta, T Arora… - Naunyn-Schmiedeberg's …, 2010 - Springer
Carbamate pesticides like propoxur have been shown to adversely affect memory and
induce oxidative stress on both acute and chronic exposure. The present study was …

The effects of lindane, DDT, and chlordecone on avoidance responding and seizure activity

HA Tilson, S Shaw, RL McLamb - Toxicology and applied pharmacology, 1987 - Elsevier
Male adult Fischer-344 rats were given various doses of lindane (0, 15, and 30 mg/kg, po),
chlordecone (0, 25, 50, or 100 mg/kg, ip), or p, p′-dichlorodiphenyltrichloroethane (p, p …

Reversal of lindane-induced impairment of step-down passive avoidance and oxidative stress by neurosteroids in rats

K Sahaya, P Mahajan, PK Mediratta, RS Ahmed… - Toxicology, 2007 - Elsevier
Neurosteroids (NS) are recognized as important modulators of functioning of the nervous
system. Lindane, an organochlorine pesticide has been shown to adversely affect memory …

Toxicology of organochlorine insecticide

AG Smith - Pesticide toxicology and international regulation, 2004 - Wiley Online Library
Although the organochlorine insecticides were widely used in agriculture and malarial
control programs from the 1940s to 1960s with dramatic benefits, they fell into disfavour …

GABAergic Neurotransmission and Toxicity 1: Organochlorines

AG Smith - 2024 - books.rsc.org
A huge number of organic chemicals, some of them are natural products, were chlorinated
cheaply in the middle of the 20th century, giving many polychlorinated products that were …

“Central” and “peripheral” benzodiazepines and kinetics of lindane-induced toxicity

JA Griffith, DE Woolley - Pharmacology Biochemistry and Behavior, 1989 - Elsevier
Because hypothermia and anorexia were previously found to be more sensitive indices of
the effects of lindane than were convulsions, these endpoints were used to quantify the …

Kinetics and thresholds of several indices of lindane-induced toxicity

DE Woolley, JA Griffith - Pharmacology Biochemistry and Behavior, 1989 - Elsevier
The effects of lindane, administered either IP (4, 6 or 8 mg/kg in dimethylsulfoxide, 0.5 ml/kg)
or PO (30, 40 or 50 mg/kg in oil, 1 ml/kg), were compared in male rats. Effects appeared later …