Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …

Cefepime is a broad-spectrum fourth-generation cephalosporin with activity against Gram-
positive and Gram-negative pathogens. It is generally administered as an infusion over 30 …

OBJECTIVES: Beta-lactam antibiotics exhibit high interindividual variability in drug
concentrations in patients with critical illness which led to an interest in the use of …

Although available data are still limited, real-world evidence regarding mainly ceftolozane-
tazobactam and ceftazidime-avibactam could support the administration of novel beta …

Importance There is uncertainty about whether prolonged infusions of β-lactam antibiotics
improve clinically important outcomes in critically ill adults with sepsis or septic shock …

OBJECTIVE: β-lactams are the cornerstone of empiric and targeted antibiotic therapy for
critically ill patients. Recently, there have been calls to use β-lactam therapeutic drug …

Antimicrobial resistance (AMR) represents a critical global threat, compromising the
effectiveness of antibacterial drugs as bacteria adapt and survive exposure to many classes …

Antimicrobial prescription in critically ill patients represents a complex challenge due to the
difficult balance between infection treatment and toxicity prevention. Underexposure to …

The surge in antimicrobial resistance and the limited availability of new antimicrobial drugs
has fueled the interest in optimizing antibiotic dosing. An ideal dosing regimen leads to …

Introduction Antibiotics are commonly prescribed in critical care, and given the large
variability of pharmacokinetic (PK) parameters in these patients, drug PK frequently varies …