In 2010, the Mediterranean diet was recognized by UNESCO as an Intangible Cultural
Heritage of Humanity. Olive oil is the most characteristic food of this diet due to its high …

Bile acids are important physiological agents for intestinal nutrient absorption and biliary
secretion of lipids, toxic metabolites, and xenobiotics. Bile acids also are signaling …

The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These
transcription factors control the expression of a battery of genes involved in the uptake …

Liver X receptors (LXRs) are transcriptional regulators of cellular and systemic cholesterol
homeostasis. Under conditions of excess cholesterol, LXR activation induces the expression …

Abstract The Liver X Receptors (LXRs) are oxysterol-activated transcription factors that
upregulate a suite of genes that together promote coordinated mobilization of excess …

Chronic, low-grade inflammation triggered by excess intake of dietary lipids has been
proposed to contribute to the pathogenesis of metabolic disorders, such as obesity, insulin …

Liver X receptors (LXRs) are regulators of cholesterol metabolism that also modulate
immune responses. Inactivation of LXR α and β in mice leads to autoimmunity; however …

Retinoid X receptors (RXRs) form a distinct and unique subclass within the nuclear receptor
(NR) superfamily of ligand-dependent transcription factors. RXRs regulate a plethora of …

The nuclear receptor superfamily includes many receptors, identified based on their
similarity to steroid hormone receptors but without a known ligand. The study of how these …

Liver X receptor α (LXRα; also known as NR1H3), an isoform of LXRs, is a member of the
nuclear receptor family of transcription factors and plays essential roles in the transcriptional …