Platelets play a central role in the arrest of bleeding after damage to a blood vessel and in
the development of thrombosis. Platelets rapidly respond after interaction with sub …

A normal hemostatic response to vascular injury requires both factor VIII (FVIII) and von
Willebrand factor (VWF). In plasma, VWF and FVIII normally circulate as a noncovalent …

Cargo sorting to intraluminal vesicles (ILVs) of multivesicular endosomes is required for
lysosome-related organelle (LRO) biogenesis. PMEL—a component of melanocyte LROs …

Cytotoxic T lymphocytes (CTLs) play a critical role in the immune system; they are able to
recognize and destroy virally infected and tumorigenic cells. Specific recognition of MHC …

Vascular endothelial cells produce and release compounds regulating vascular tone, blood
vessel growth and differentiation, plasma composition, coagulation and fibrinolysis, and also …

Some cells harbour specialised lysosome-related organelles (LROs) that share features of
late endosomes/lysosomes but are functionally, morphologically and/or compositionally …

Endothelial cells respond to vascular endothelial growth factor (VEGF) to produce new
blood vessels. This process of angiogenesis makes a critical contribution during …

Endothelial cells store the adhesive glycoprotein von Willebrand factor (VWF) in Weibel-
Palade bodies (WPBs), distinctively shaped regulated secretory organelles that undergo …

Retroviral Gag proteins are membrane‐bound polyproteins that are necessary and sufficient
for virus‐like particle (VLP) formation. It is not known how Gag traffics through the cell or how …

Weibel-Palade bodies are the 1–5 μm long rod-shaped storage organelles of endothelial
cells. We have investigated the determinants and functional significance of this shape. We …